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. 2018 Jun 20;218(2):234-238.
doi: 10.1093/infdis/jiy011.

Cumulative Antiretroviral Exposure Measured in Hair Is Not Associated With Measures of HIV Persistence or Inflammation Among Individuals on Suppressive ART

Monica Gandhi  1 , Rajesh T Gandhi  2 , Andrei Stefanescu  3 , Ronald J Bosch  3 , Joshua C Cyktor  4 , Howard Horng  1 , Alexander Louie  1 , Nhi Phung  1 , Joseph J Eron  5 , Evelyn Hogg  6 , Bernard J C Macatangay  4 , Christopher Hensel  7 , Courtney V Fletcher  8 , John W Mellors  4 , Deborah K McMahon  4 ; A5321 Team
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Cumulative Antiretroviral Exposure Measured in Hair Is Not Associated With Measures of HIV Persistence or Inflammation Among Individuals on Suppressive ART

Monica Gandhi et al. J Infect Dis. .

Abstract

Data on the relationship of antiretroviral exposure to measures of human immunodeficiency virus (HIV) persistence are limited. To address this gap, multiple viral, immunologic, and pharmacologic measures were analyzed from individuals with sustained virologic suppression on therapy (median 7 years) in the AIDS Clinical Trials Group A5321 cohort. Among 110 participants on tenofovir-(TFV)-disoproxil-fumarate (TDF)/emtricitabine (FTC)-containing regimens, we found no significant correlation between hair concentrations of individual antiretrovirals (ARVs) in the regimen and measures of HIV persistence (plasma HIV-1 RNA by single copy assay, cell-associated-DNA, cell-associated RNA) or soluble markers of inflammation. These findings suggest that higher systemic ARV exposure may not impact HIV persistence or inflammation.

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Figures

Figure 1.
Figure 1.
Interindividual variability in antiretroviral (ARV) concentrations seen even among virologically suppressed individuals. ARV concentrations in hair below the lower limit of quantification were set to 0.001. Abbreviations: ATV, atazanavir; DRV, darunavir; EFV, efavirenz; FTC, emtricitabine; NVP, nevirapine; RAL, raltegravir; TFV, tenofovir.
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