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. 2018 Jan-Dec:17:2325958218759759.
doi: 10.1177/2325958218759759.

Incidence and Risk Factors for Overweight and Obesity after Initiation of Antiretroviral Therapy in Dar es Salaam, Tanzania

Alexander Kintu  1 , Enju Liu  2 , Ellen Hertzmark  2   3   4 , Donna Spiegelman  2   3   4 , Rachel Margaret Zack  3 , Aisa Muya  5 , David Sando  1   5 , Till Bärnighausen  1 , Wafaie Fawzi  1   2   3
Affiliations

Incidence and Risk Factors for Overweight and Obesity after Initiation of Antiretroviral Therapy in Dar es Salaam, Tanzania

Alexander Kintu et al. J Int Assoc Provid AIDS Care. 2018 Jan-Dec.

Abstract

Objective: To describe the incidence of and risk factors for overweight and obesity following antiretroviral therapy (ART) initiation.

Methods: We used Cox proportional hazards models to investigate risk factors for incident overweight and obesity in 79 074 individuals aged 15 years or older who initiated ART in Dar es Salaam, Tanzania.

Results: Twenty-five percent of the patients became overweight and 10% became obese. The incidence rate of obesity was 3.2 per 100 person-years (95% confidence interval [CI]: 3.1-3.3) in patients who were of normal weight before starting ART and 22.6 per 100 person-years (95% CI: 21.9-23.3) in those who were overweight. Lower CD4 count was associated with a higher risk of overweight and obesity ( P value for trend < .0001).

Conclusion: There is a high burden of overweight and obesity after starting ART, leading to proportions of these 2 conditions that are similar to those in the general population.

Keywords: antiretroviral therapy; incidence; obesity; overweight; risk factors.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Cumulative incidence of overweight (A) and obesity (B) after ART initiation. ART indicates antiretroviral therapy.
See this image and copyright information in PMC

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