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. 2018 Mar 12;18(1):280.
doi: 10.1186/s12885-018-4182-3.

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Trinidad Dierssen-Sotos  1   2 , Camilo Palazuelos-Calderón  1 , José-Juan Jiménez-Moleón  2   3 , Nuria Aragonés  2   4   5 , Jone M Altzibar  2   6 , Gemma Castaño-Vinyals  2   7   8   9 , Vicente Martín-Sanchez  2   10 , Inés Gómez-Acebo  1   2 , Marcela Guevara  2   11 , Adonina Tardón  2   12 , Beatriz Pérez-Gómez  2   4   5 , Pilar Amiano  2   13 , Victor Moreno  2   14   15 , Antonio J Molina  10 , Jéssica Alonso-Molero  1 , Conchi Moreno-Iribas  11   16 , Manolis Kogevinas  2   7   8   9 , Marina Pollán  2   4   5 , Javier Llorca  17   18   19
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Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Trinidad Dierssen-Sotos et al. BMC Cancer. .

Abstract

Background: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship.

Methods: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression.

Results: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced.

Conclusions: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.

Keywords: Breast cancer; Genetic interactions; Reproductive factors.

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Conflict of interest statement

Ethics approval and consent to participate

Participants who agreed to partake in the study signed an informed consent before the face-to-face interview, and the protocol of MCC-Spain was approved by the local Ethics Committees of participating institutions (Comité Ético de Investigación Clínica (CEIC) del Instituto Municipal de Asistencia Sanitaria de Barcelona; CEIC del Hospital Universitario de Bellvitge; CEIC de Navarra; CEIC del Hospital Universitario La Paz; CEIC del Hospital Universitario Ramón y Cajal; CEIC de Cantabria; CEIC de Gipuzkoa; CEIC de Girona; Comité de Ética de la Investigación de la Provincia de Huelva; CEIC de León; Comité Ético de Investigación del Principado de Asturias), in conformity with the principles of the Declaration of Helsinki. The database was registered in the Spanish Agency for Data Protection (no. 2102672171).

Consent for publication

Not applicable.

Competing interests

All authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Recruitment procedure in the MCC-Spain study
See this image and copyright information in PMC

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