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. 2018 Mar;20(3):195-199.
doi: 10.7499/j.issn.1008-8830.2018.03.006.

[Current status of vitamin A deficiency in preschool children in Dongguan, China and the effect of vitamin A on serum ferritin and red blood cell parameters]

[Article in Chinese]
Zhen-Hong Zhang  1 , Ming Ni, Yuan Hu
Affiliations

[Current status of vitamin A deficiency in preschool children in Dongguan, China and the effect of vitamin A on serum ferritin and red blood cell parameters]

[Article in Chinese]
Zhen-Hong Zhang et al. Zhongguo Dang Dai Er Ke Za Zhi. 2018 Mar.

Abstract
in English, Chinese

Objective: To investigate the current status of vitamin A deficiency in preschool children in Dongguan, China, as well as the effect of vitamin A on serum ferritin, red blood cell, and reticulocyte parameters.

Methods: Cluster sampling was performed from April 2015 to December 2016 to select 2 085 preschool children (3-6 years old) without any disease in Dongguan. Routine blood test, reticulocyte count, serum ferritin measurement, hemoglobin electrophoresis, and vitamin A measurement were performed for all children. The associations of age and sex with vitamin A and serum ferritin concentrations were analyzed. The effect of vitamin A concentration on serum ferritin, red blood cell, and reticulocyte parameters and the effect of reduced iron storage caused by vitamin A deficiency on red blood cell parameters were evaluated.

Results: Of the 2 085 children, 140 (6.71%) had reduced iron storage, and 678 (32.52%) had vitamin A deficiency. Among the 678 children with vitamin A deficiency, 647 (95.4%) had subclinical deficiency and 31 (4.6%) had clinical deficiency. There was no significant difference in vitamin A concentration between boys and girls, however girls had a significantly higher serum ferritin concentration than boys (P<0.05). The clinical vitamin A deficiency group had a significantly higher serum ferritin concentration than the subclinical vitamin A deficiency group and the normal group (P<0.05). In cases of vitamin A deficiency, the reduced iron storage group had significant reductions in mean corpuscular volume and mean corpuscular hemoglobin than the normal iron storage group (P<0.05). Compared with the normal vitamin A group, the vitamin A deficiency group had significantly lower hemoglobin concentration, mean corpuscular hemoglobin, red blood cell count, hematocrit, absolute reticulocyte count, reticulocyte percentage, and reticulocyte hemoglobin content, as well as a significantly higher mean corpuscular volume (P<0.05).

Conclusions: Vitamin A deficiency is prevalent in preschool children in Dongguan, China, and it may adversely affect serum ferritin, red blood cell, and reticulocyte parameters.

目的: 了解东莞市学龄前儿童维生素A缺乏现状, 探讨维生素A对血清铁蛋白、红细胞及网织红细胞参数的影响。

方法: 于2015年4月至2016年12月通过整群抽样方法, 选取东莞市无现患疾病的学龄前儿童(3~6岁)2 085例, 对所选儿童进行血常规、网织红细胞计数、血清铁蛋白、血红蛋白电泳及维生素A浓度检测。分析年龄、性别与维生素A浓度及血清铁蛋白浓度的关系, 维生素A浓度对血清铁蛋白、红细胞及网织红细胞参数的影响以及维生素A缺乏加重储存铁减少对红细胞参数的影响。

结果: 储存铁减少的儿童占比为6.71%(140/2 085);维生素A缺乏儿童占比为32.52%(678/2 085), 其中亚临床缺乏占维生素A缺乏总人数的95.4%(647/678), 临床缺乏占维生素A缺乏总人数的4.6%(31/678)。不同性别组儿童维生素A浓度比较差异无统计学意义(P > 0.05), 但女性儿童血清铁蛋白浓度高于男性(P < 0.05)。维生素A临床缺乏组儿童血清铁蛋白浓度高于亚临床缺乏组和正常组(P < 0.05)。维生素A缺乏时, 储存铁减少组平均红细胞体积和平均红细胞血红蛋白含量较储存铁正常组降低(P < 0.05)。维生素A缺乏组血红蛋白浓度、平均红细胞血红蛋白浓度、红细胞计数、红细胞压积、网织红细胞绝对值、网织红细胞百分比、网织红细胞血红蛋白含量均低于维生素A正常组, 而平均红细胞体积高于维生素A正常组(P < 0.05)。

结论: 东莞市学龄前儿童维生素A缺乏状况仍较严重; 维生素A缺乏可对血清铁蛋白、红细胞以及网织红细胞参数产生影响。

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References

    1. 杨 春, 杨 晓光. 中国人群维生素A的影响因素. http://d.old.wanfangdata.com.cn/Periodical/yxzs201607001. 医学综述. 2016;22(7):1249–1252. - PubMed
    1. 李 文迪, 魏 守磊, 彭 云, et al. 新生儿维生素A缺乏的研究进展. 中国儿童保健杂志. 2017;25(8):799–802. doi: 10.11852/zgetbjzz2017-25-08-13. - DOI
    1. 金 鹿, 闫 素梅, 史 彬林, et al. 维生素A抗氧化功能的机制. 动物营养学报. 2015;27(12):3671–3676. doi: 10.3969/j.issn.1006-267x.2015.12.004. - DOI - PubMed
    1. da Cunha MS, Siqueira EM, Trindade LS, et al. Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis. J Nutr Biochem. 2014;25(10):1035–1044. doi: 10.1016/j.jnutbio.2014.05.005. - DOI - PubMed
    1. 周 楠. 我国学龄前儿童家庭喂养状况研究进展. http://d.old.wanfangdata.com.cn/Periodical/zgxxws201711048 中国学校卫生. 2017;38(11):1757–1760. - PubMed