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Case Reports
. 2018 Apr 26;62(5):e02130-17.
doi: 10.1128/AAC.02130-17. Print 2018 May.

Posaconazole-Induced Pseudohyperaldosteronism

Kevin Kuriakose  1 , Whitney J Nesbitt  2 , Matthew Greene  3 , Bryan Harris  3
Affiliations
Case Reports

Posaconazole-Induced Pseudohyperaldosteronism

Kevin Kuriakose et al. Antimicrob Agents Chemother. .

Abstract

A woman in her late 60s with disseminated histoplasmosis was treated with posaconazole because first-line therapies were not tolerated. She subsequently presented with decompensated heart failure, hypertension, and hypokalemia. Laboratory tests revealed low renin and aldosterone levels. A potential mechanism is inhibition of the enzyme 11β-hydroxysteroid dehydrogenase 2, with resultant apparent mineralocorticoid excess.

Keywords: aldosterone; hypertension; hypokalemia; mineralocorticoid; posaconazole; pseudohyperaldosteronism.

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