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. 2018 Apr 26;62(5):e02380-17.
doi: 10.1128/AAC.02380-17. Print 2018 May.

In Vitro Activity of Lefamulin against Sexually Transmitted Bacterial Pathogens

Susanne Paukner  1 , Astrid Gruss  2 , Jørgen Skov Jensen  3
Affiliations

In Vitro Activity of Lefamulin against Sexually Transmitted Bacterial Pathogens

Susanne Paukner et al. Antimicrob Agents Chemother. .

Abstract

The pleuromutilin antibiotic lefamulin demonstrated in vitro activity against the most relevant bacterial pathogens causing sexually transmitted infections (STI), including Chlamydia trachomatis (MIC50/90, 0.02/0.04 mg/liter; n = 15), susceptible and multidrug-resistant Mycoplasma genitalium (MIC range, 0.002 to 0.063 mg/liter; n = 6), and susceptible and resistant Neisseria gonorrhoeae (MIC50/90, 0.12/0.5 mg/liter; n = 25). The results suggest that lefamulin could be a promising first-line antibiotic for the treatment of STI, particularly in populations with high rates of resistance to standard-of-care antibiotics.

Keywords: Chlamydia trachomatis; Mycoplasma genitalium; Neisseria gonorrhoeae; lefamulin; pleuromutilin; sexually transmitted diseases; sexually transmitted infection.

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