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. 2018 Feb 28:12:1178223418759959.
doi: 10.1177/1178223418759959. eCollection 2018.

Analysis of Trends and Factors in Breast Multiple Primary Malignant Neoplasms

Igor Motuzyuk  1 , Oleg Sydorchuk  1 , Natalia Kovtun  2   3 , Zinaida Palian  3 , Yevhenii Kostiuchenko  1
Affiliations

Analysis of Trends and Factors in Breast Multiple Primary Malignant Neoplasms

Igor Motuzyuk et al. Breast Cancer (Auckl). .

Abstract

Background: The study aims to evaluate the current state and tendencies in multiple primary breast cancer incidence, behavior, and treatment in Ukraine.

Methods: A total of 2032 patients who received special treatment at the Department of Breast Tumors and Reconstructive Surgery of the National Cancer Institute from 2008 to 2015 were included in the study. Among them, there were 195 patients with multiple primary malignant neoplasms: 54.9% patients with synchronous cancer and 45.1% patients with metachronous cancer. The average age of patients was 46.6 years, and the percentage of postmenopausal women was 63.1%. Among patients with synchronous cancer, there were 56.1% patients with only breast localizations and 43.9% with combination of breast and other localizations, and among patients with metachronous cancer, there were 46.6% patients with only breast localizations and 53.4% with combination of breast and other localizations. All the patients were evaluated in terms of aggressiveness of the disease, survival rates, as well as risk factors and treatment options.

Results: A more aggressive course of breast cancer is observed in patients exposed to radiation from the Chernobyl accident under the age of 30 years (P < .01). The clinical course of disease in patients with synchronous cancer is worse and prognostically unfavorable compared with metachronous cancer (P < .01). The course of the disease in patients who underwent mastectomy is worse compared with patients who underwent breast-conserving surgery (P < .01). Plastic and reconstructive surgery in patients with synchronous cancer was proven to be reasonable in terms of increase in survival (P < .01).

Conclusions: The patients with multiple primary breast cancer should have attentive management and treatment. Multidisciplinary team should concern all the risk factors and provide the most sufficient option of management. This is crucial to continue research in this oncological area.

Keywords: Multiple primary synchronous and metachronous breast cancer; breast reconstruction surgery.

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Conflict of interest statement

Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Cumulative share of survived patients depending on the moment when the first diagnosis was made according to Kaplan-Meier (before 2008—group 1 and after 2008—group 2). P = .032.
Figure 2.
Figure 2.
Cumulative share of overall survived patients depending of the stage according to Kaplan-Meier. P = .013.
See this image and copyright information in PMC

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