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. 2017 Summer;12(3):202-208.
Epub 2017 Jul 1.

The Core Needle and Surgical Biopsy Concordance to Detect Estrogen, Progesterone, and Her-2 Receptors in Breast Cancer: A Comparative Study

Fereshteh Ensani  1 , Ramesh Omranipour  2 , Isa Jahanzad  3 , Azadeh Jafari  1 , Shima Nafarzadeh  4 , Pouyan Aminishakib  5
Affiliations

The Core Needle and Surgical Biopsy Concordance to Detect Estrogen, Progesterone, and Her-2 Receptors in Breast Cancer: A Comparative Study

Fereshteh Ensani et al. Iran J Pathol. 2017 Summer.

Abstract

Background &objectives: Evaluation of estrogen receptor (ER), progesterone receptor (PR), and (human epidermal growth factor receptor-2) Her-2 on core needle biopsies (CNBs) is increasingly in use to diagnosis early breast cancer, but its concordance with surgical excision (SE) is not well documented.

Methods: The study included 100 formalin fixed, paraffin-embedded specimens of invasive breast carcinoma archived in Pathology Department of Cancer Institute, Tehran, Iran, from 2011 to 2014. Immunohistochemistry was applied to detect ER, PR, and Her-2.

Results: The current study findings indicated a significant correlation of 90% between CNB and SE specimens for ER expression. The correlation between CNB and SE specimens was estimated as 81% and 97.3% for PR and Her-2, respectively.

Discussion: CNB can be performed confidently to determine ER and Her-2. For PR, results obtained from CNB should be considered.

Keywords: Breast Cancer; Core Needle Biopsy; Estrogen; Her-2; Progesterone.

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Conflict of interest statement

The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
Strong ER staining in more than 75% of tumoral cells (×100)
Figure 2
Figure 2
Strong PR staining in more than 75%of tumoral cells (×100)
Figure 3
Figure 3
Circumferential and intense, complete staining of Her-2 in more than 10% of tumoral cells (×100).
See this image and copyright information in PMC

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