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. 2018 Feb 5;8(1):62-69.
eCollection 2018.

Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease

Onofrio Antonio Catalano  1   2   3 , Vincent Wu  2 , Umar Mahmood  4 , Alberto Signore  5   3 , Mark Vangel  6 , Andrea Soricelli  7 , Marco Salvatore  8 , Debra Gervais  2 , Bruce R Rosen  1
Affiliations

Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease

Onofrio Antonio Catalano et al. Am J Nucl Med Mol Imaging. .

Abstract

This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease.

Keywords: Crohn disease; PET/MR; active inflammation; inflammation.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Concordance of PET and MR in correctly identifying active inflammation. Coronal PET (A), coronal CE-VIBE (B), fused PET/MR (C). An actively inflamed bowel loop (arrow) demonstrates wall thickening, pronounced enhancement, and marked FDG uptake (arrow).
Figure 2
Figure 2
False positive PET case. Axial PET (A), axial T2-weighted HASTE (B), axial CE-VIBE (C), and fused PET/MR (D). A focal area of marked FDG uptake was identified in the distal ileum/ileocecal valve (arrow). However, no bowel wall thickening or hyperenhancement was seen in this region on MR. Additionally, no active bowel inflammation was observed in this region during surgery.
Figure 3
Figure 3
False positive MR case. Coronal PET (A), coronal CE-VIBE (B), and fused PET/MR (C). A segment of bowel wall thickening with abnormal hyperenhancement was identified in the left lower quadrant of the abdomen on MR (arrow). However, no FDG uptake in this region was detected on PET. Additionally, no active bowel inflammation was observed during surgery.
See this image and copyright information in PMC

References

    1. Sleisenger M, Feldman M, Friedman L, Brandt L. Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology, diagnosis, management. Philadelphia, PA: Saunders. Elsevier; 2010.
    1. Papi C, Festa V, Fagnani C, Stazi A, Antonelli G, Moretti A, Koch M, Capurso L. Evolution of clinical behaviour in Crohn’s disease: predictive factors of penetrating complications. Dig Liver Dis. 2005;37:247–253. - PubMed
    1. Hara AK, Leighton JA, Heigh RI, Sharma VK, Silva AC, De Petris G, Hentz JG, Fleischer DE. Crohn disease of the small bowel: preliminary comparison among CT enterography, capsule endoscopy, small-bowel follow-through, and ileoscopy. Radiology. 2006;238:128–134. - PubMed
    1. Bruining DH, Siddiki HA, Fletcher JG, Tremaine WJ, Sandborn WJ, Loftus EV. Prevalence of penetrating disease and extraintestinal manifestations of Crohn’s disease detected with CT enterography. Inflamm Bowel Dis. 2008;14:1701–1706. - PubMed
    1. Panes J, Bouhnik Y, Reinisch W, Stoker J, Taylor S, Baumgart D, Danese S, Halligan S, Marincek B, Matos C. Imaging techniques for assessment of inflammatory bowel disease: joint ECCO and ESGAR evidence-based consensus guidelines. J Crohns Colitis. 2013;7:556–585. - PubMed

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