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Editorial
. 2018 Feb;7(1):48-51.
doi: 10.21037/hbsn.2017.12.04.

Single cell profiling reveals window for immunotherapy in liver cancers

Jesper B Andersen  1
Affiliations
Editorial

Single cell profiling reveals window for immunotherapy in liver cancers

Jesper B Andersen. Hepatobiliary Surg Nutr. 2018 Feb.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Patient with liver cancer. The population of tumor infiltrating lymphocytes (TILs) CD4 and CD8 T cells hepatocellular carcinoma (HCC) is represented by a specific enrichment of exhausted CD8 and regulatory T cells. A signature key gene layilin (LAYN) is increased in activated CD8 and regulatory CD4 T cells and causes the repression of interferon gamma expression, which is required for active tumor cell killing. This results in the suppression of regulatory CD4 and exhaustion of CD8 T cells.
See this image and copyright information in PMC

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References

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