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Randomized Controlled Trial
. 2018 Apr 17;168(8):550-557.
doi: 10.7326/M17-2315. Epub 2018 Mar 13.

Effect of a Digital Health Intervention on Receipt of Colorectal Cancer Screening in Vulnerable Patients: A Randomized Controlled Trial

David P Miller Jr  1 , Nancy Denizard-Thompson  1 , Kathryn E Weaver  1 , L Doug Case  1 , Jennifer L Troyer  2 , John G Spangler  1 , Donna Lawler  1 , Michael P Pignone  3
Affiliations
Randomized Controlled Trial

Effect of a Digital Health Intervention on Receipt of Colorectal Cancer Screening in Vulnerable Patients: A Randomized Controlled Trial

David P Miller Jr et al. Ann Intern Med. .

Abstract

Background: Screening for colorectal cancer (CRC) reduces mortality, yet more than one third of age-eligible Americans are unscreened.

Objective: To examine the effect of a digital health intervention, Mobile Patient Technology for Health-CRC (mPATH-CRC), on rates of CRC screening.

Design: Randomized clinical trial. (ClinicalTrials.gov: NCT02088333).

Setting: 6 community-based primary care practices.

Participants: 450 patients (223 in the mPATH-CRC group and 227 in usual care) scheduled for a primary care visit and due for routine CRC screening.

Intervention: An iPad application that displays a CRC screening decision aid, lets patients order their own screening tests, and sends automated follow-up electronic messages to support patients.

Measurements: The primary outcome was chart-verified completion of CRC screening within 24 weeks. Secondary outcomes were ability to state a screening preference, intention to receive screening, screening discussions, and orders for screening tests. All outcome assessors were blinded to randomization.

Results: Baseline characteristics were similar between groups; 37% of participants had limited health literacy, and 53% had annual incomes less than $20 000. Screening was completed by 30% of mPATH-CRC participants and 15% of those receiving usual care (logistic regression odds ratio, 2.5 [95% CI, 1.6 to 4.0]). Compared with usual care, more mPATH-CRC participants could state a screening preference, planned to be screened within 6 months, discussed screening with their provider, and had a screening test ordered. Half of mPATH-CRC participants (53%; 118 of 223) "self-ordered" a test via the program.

Limitation: Participants were English speakers in a single health care system.

Conclusion: A digital health intervention that allows patients to self-order tests can increase CRC screening. Future research should identify methods for implementing similar interventions in clinical care.

Primary funding source: National Cancer Institute.

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References

    1. Inadomi JM. Screening for Colorectal Neoplasia. N Engl J Med. 2017 Jan 12;376(2):149–56. - PubMed
    1. Ladabaum U, Mannalithara A. Comparative Effectiveness and Cost Effectiveness of a Multitarget Stool DNA Test to Screen for Colorectal Neoplasia. Gastroenterology. 2016 Sep;151(3):427–439.e6. - PubMed
    1. Lin JS, Piper MA, Perdue LA, Rutter C, Webber EM, O’Connor E, et al. Screening for Colorectal Cancer: A Systematic Review for the U.S. Preventive Services Task Force. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016. Report No: 14-05203-EF-1. - PubMed
    1. Patel SS, Kilgore ML. Cost Effectiveness of Colorectal Cancer Screening Strategies. Cancer Control J Moffitt Cancer Cent. 2015 Apr;22(2):248–58. - PubMed
    1. Sharaf RN, Ladabaum U. Comparative Effectiveness and Cost-Effectiveness of Screening Colonoscopy vs. Sigmoidoscopy and Alternative Strategies. Am J Gastroenterol. 2013 Jan;108(1):120–32. - PubMed

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