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Comment
. 2018 Apr;15(4):402-404.
doi: 10.1038/cmi.2017.80. Epub 2017 Sep 4.

miRNA-31 regulates the CD8 T cell response to type I IFNs during chronic infection

Marta Catalfamo  1
Affiliations
Comment

miRNA-31 regulates the CD8 T cell response to type I IFNs during chronic infection

Marta Catalfamo. Cell Mol Immunol. 2018 Apr.
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
miRNA-31 modulates the type I IFN response in CD8 T cells. The in vitro miRNA-31 target gene, Ppp6c, regulates the sensitivity of the type I IFN response. miR-31-deficient CD8 T cells were infected with a lentiviral vector expressing miRNA-31 or shRNA targeting Ppp6c to assess the in vitro response to IFN-β. Activation was measured by the detection of CD69 upregulation using flow cytometry. Expression of miRNA-31 or silencing Ppp6c enhanced CD69 upregulation (relative to control lentivirus) after in vitro stimulation with IFN-β. miR-31 regulates T-cell exhaustion during chronic infection. During the chronic phase of an infection with LCMV clone 13, miR-31-deficient mice recovered and showed no signs of disease compared with wild-type mice. Viral control in the miR-31-deficient mice was associated with increased polyfunctional virus-specific CD8 T cells with effector and effector memory phenotypes and low PD1 expression.
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References

    1. Deeks SG, Odorizzi PM, Sekaly RP. The interferon paradox: can inhibiting an antiviral mechanism advance an HIV cure? J Clin Invest. 2017;127:103–105. doi: 10.1172/JCI91916. - DOI - PMC - PubMed
    1. Doyle T, Goujon C, Malim MH. HIV-1 and interferons: who's interfering with whom? Nat Rev Microbiol. 2015;13:403–413. doi: 10.1038/nrmicro3449. - DOI - PMC - PubMed
    1. Kaech SM, Cui W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev. 2012;12:749–761. - PMC - PubMed
    1. Gracias DT, Katsikis PD. MicroRNAs: key components of immune regulation. Adv Exp Med Biol. 2011;780:15–26. doi: 10.1007/978-1-4419-5632-3_2. - DOI - PubMed
    1. Mehta A, Baltimore D. MicroRNAs as regulatory elements in immune system logic. Nat Rev. 2016;16:279–294. - PubMed