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. 2018 May;93(5):499-503.
doi: 10.1002/cyto.a.23357. Epub 2018 Mar 13.

OMIP-046: Characterization of invariant T cell subset activation in humans

Kerri G Lal  1   2   3 , Edwin Leeansyah  3   4 , Johan K Sandberg  3 , Michael A Eller  1   2
Affiliations

OMIP-046: Characterization of invariant T cell subset activation in humans

Kerri G Lal et al. Cytometry A. 2018 May.
No abstract available

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Figures

Figure 1.
Figure 1.
Gating strategy and performance of OMIP-046. (A) Gating strategy of time, singlets, lymphocytes, living cells and T cells, (B) followed by T cell subsets, and (C) quadrant gating on activation markers for the four T cell subsets of interest CD4 T (green), CD8 T (purple), MAIT (red) and iNKT cells (orange). (D) Pie charts show the coexpression of activation markers as defined by Boolean gating. Arcs indicate expression of individual activation markers, and colored pie slices indicate the frequency of subsets expressing varying combinations of these markers. Pie charts illustrate the variety of phenotypes represented using this OMIP, and compare T cell subsets in 13 HIV-donors to 13 HIV+ donors.
See this image and copyright information in PMC

References

    1. Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB, The burgeoning family of unconventional T cells. Nat Immunol 16, 1114–1123 (2015). - PubMed
    1. Dellabona P et al., In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8-subset. J Exp Med 177, 1763–1771 (1993). - PMC - PubMed
    1. Dellabona P, Padovan E, Casorati G, Brockhaus M, Lanzavecchia A, An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8-T cells. J Exp Med 180, 1171–1176 (1994). - PMC - PubMed
    1. Kronenberg M, When less is more: T lymphocyte populations with restricted antigen receptor diversity. J Immunol 193, 975–976 (2014). - PubMed
    1. Lantz O, Bendelac A, An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J Exp Med 180, 1097–1106 (1994). - PMC - PubMed

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