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Comment
. 2018 Mar 12;33(3):342-343.
doi: 10.1016/j.ccell.2018.02.014.

ORY-1001: Overcoming the Differentiation Block in AML

Prithviraj Bose  1 , Marina Y Konopleva  2
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ORY-1001: Overcoming the Differentiation Block in AML

Prithviraj Bose et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Maes and colleagues report in vitro and in vivo findings with ORY-1001-an oral, highly potent and selective covalent small-molecule inhibitor of lysine-specific demethylase 1 (LSD1)-in development for acute myeloid leukemia (AML), as well as correlative data from two AML patients receiving ORY-1001.

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