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Comment
. 2018 Mar 12;33(3):344-346.
doi: 10.1016/j.ccell.2018.02.013.

A Non-canonical Polycomb Dependency in Synovial Sarcoma

Joshua J Waterfall  1 , Paul S Meltzer  2
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Comment

A Non-canonical Polycomb Dependency in Synovial Sarcoma

Joshua J Waterfall et al. Cancer Cell. .
Free article

Abstract

Disruptions in the antagonistic balance between the chromatin-modifying Polycomb and Trithorax group proteins drive many malignancies. In this issue of Cancer Cell, Banito et al. describe how the SS18-SSX oncogenic fusion protein in synovial sarcoma directly co-opts these complexes to drive gene dysregulation and sustain the transformed state.

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  • The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma.
    Banito A, Li X, Laporte AN, Roe JS, Sanchez-Vega F, Huang CH, Dancsok AR, Hatzi K, Chen CC, Tschaharganeh DF, Chandwani R, Tasdemir N, Jones KB, Capecchi MR, Vakoc CR, Schultz N, Ladanyi M, Nielsen TO, Lowe SW. Banito A, et al. Cancer Cell. 2018 Mar 12;33(3):527-541.e8. doi: 10.1016/j.ccell.2018.01.018. Epub 2018 Mar 1. Cancer Cell. 2018. PMID: 29502955 Free PMC article.

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