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. 2018 Aug 1;67(4):624-627.
doi: 10.1093/cid/ciy209.

Prolonged Detection of Zika Virus Nucleic Acid Among Symptomatic Pregnant Women: A Cohort Study

Matthew J Lozier  1 , Eli S Rosenberg  2 , Kate Doyle  3 , Laura Adams  1 , Liore Klein  4 , Jorge Muñoz-Jordan  1 , Luisa I Alvarado  5 , Tyler M Sharp  1 , Gabriela Paz-Bailey  1
Affiliations

Prolonged Detection of Zika Virus Nucleic Acid Among Symptomatic Pregnant Women: A Cohort Study

Matthew J Lozier et al. Clin Infect Dis. .

Abstract

A prospective cohort of women with reverse transcription polymerase chain reaction (RT-PCR) confirmed Zika virus infection aged 18-39 years in Puerto Rico found that pregnant women have about a 3-fold longer estimated median detection of Zika virus RNA in serum, which can increase definitive diagnosis of infection and facilitate timely and appropriate clinical management.

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Figures

Figure 1.
Figure 1.
Detection of Zika virus RNA in the serum of pregnant women aged 18–39 years (n = 9) enrolled in the Zika Virus Persistence Study in Puerto Rico, 2016–2017. Numbers below the PCR results indicate the days post symptom onset of specimen collection. Last day of pregnancy for line 3 is an estimate within one week. The lower and upper intervals used in statistical modeling are shown for each pregnant woman. PCR positive results = CT value <38; Below threshold of detection = CT value >38–≤40; PCR negative = CT value >40. Abbreviations: CT, cycle threshold; PCR, polymerase chain reaction.
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