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. 2018 Jan-Dec:17:2325958218759761.
doi: 10.1177/2325958218759761.

High Prevalence of Antibiotic-Resistant Otitis Media-Associated Bacterial Flora of Asymptomatic People Living with HIV at Morogoro Hospital, Tanzania

Kennedy Daniel Mwambete  1 , Mathias Eulambius  2
Affiliations

High Prevalence of Antibiotic-Resistant Otitis Media-Associated Bacterial Flora of Asymptomatic People Living with HIV at Morogoro Hospital, Tanzania

Kennedy Daniel Mwambete et al. J Int Assoc Provid AIDS Care. 2018 Jan-Dec.

Abstract

Objectives: The study aimed to determine the prevalence of otitis media (OM)-associated bacterial flora of asymptomatic people living with HIV (PLH) on antiretroviral therapy (ART) and assess antibiotic resistance profiles of the bacteria.

Methodology: Ear secretion specimens were collected by syringe or cotton swabs. Isolated bacteria were subjected to antibiotic sensitivity tests.

Results: Of 290 recruited PLH, 81.7% were females and 18.3% males; their CD4+ counts ranged from 0 to 1770. Staphylococcus aureus, Klebsiella pneumonia, and Escherichia coli were the predominant bacteria. High antibiotic resistance was detected on Streptococcus pyogenes and Streptococcus pneumoniae. The prevalence rate of OM-associated bacteria (OAB) was 93.4%, and majority of the bacteria were resistant to multiple antibiotics. Linear association between the prevalence of OAB with both duration of ART and CD4+ counts was observed.

Conclusion: High prevalence rates of OAB and antibiotic resistance were observed. Negative correlation between CD4+ counts and prevalence of OAB was revealed.

Keywords: HIV/AIDS; antibiotic resistance; otitis media–associated bacteria.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Patients’ immunological status/ CD4+ T cell counts in relation to ages and occurrence of OAB.
Figure 2.
Figure 2.
Patients’ immunological status in relation to duration of ART and OAB.
See this image and copyright information in PMC

References

    1. Hrapcak S, Kuper H, Bartlett P, et al. Hearing loss in HIV-infected children in Lilongwe, Malawi. PloS One. 2016;11(8):e0161421. - PMC - PubMed
    1. Luzuriaga K, Mofenson LM. Challenges in the elimination of pediatric HIV-1 infection. N Engl J Med. 2016;374(8):761–770. - PubMed
    1. Qureishi A, Lee Y, Belfield K, Birchall JP, Daniel M. Update on otitis media—prevention and treatment. Infect Drug Resist. 2014;7:15–24. - PMC - PubMed
    1. Smith AF, Ianacone DC, Ensink RJ, Melaku A, Casselbrant ML, Isaacson G. Prevalence of hearing-loss among HAART-treated children in the Horn of Africa. Int J Pediatr Otorhinolaryngol. 2017;98:166–170. - PubMed
    1. Zahid T, Ahmed Z, Aqeel Z. Microbiology of chronic suppurative otitis media (CSOM) in tertiary care setup, Civil Hospital Karachi, Pakistan. Pak J Surg, 2016;32(3):176–180.

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