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Review
. 2018 Mar 13;131(5):jcs209890.
doi: 10.1242/jcs.209890.

Formation of COPI-coated vesicles at a glance

Eric C Arakel  1 , Blanche Schwappach  2   3
Affiliations
Review

Formation of COPI-coated vesicles at a glance

Eric C Arakel et al. J Cell Sci. .

Erratum in

Abstract

The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the identity of the early secretory pathway and impinges on key cellular processes, such as protein quality control. In this Cell Science at a Glance and accompanying poster, we illustrate the different stages of COPI-coated vesicle formation and revisit decades of research in the context of recent advances in the elucidation of COPI coat structure. By calling attention to an array of questions that have remained unresolved, this review attempts to refocus the perspectives of the field.

Keywords: Arf1; ArfGAP; COPI; Coatomer; Endoplasmic reticulum; Golgi; Vesicle coat.

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