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Review
. 2018 Mar 1:11:299-306.
doi: 10.2147/IDR.S123887. eCollection 2018.

Multidrug-resistant malaria and the impact of mass drug administration

Janie Anne Zuber  1 , Shannon Takala-Harrison  1
Affiliations
Review

Multidrug-resistant malaria and the impact of mass drug administration

Janie Anne Zuber et al. Infect Drug Resist. .

Abstract

Based on the emergence and spread throughout the Greater Mekong Subregion (GMS) of multiple artemisinin-resistant lineages, the prevalence of multidrug resistance leading to high rates of artemisinin-based combination treatment failure in parts of the GMS, and the declining malaria burden in the region, the World Health Organization has recommended complete elimination of falciparum malaria from the GMS. Mass drug administration (MDA) is being piloted as one elimination intervention to be employed as part of this effort. However, concerns remain as to whether MDA might exacerbate the already prevalent problem of multidrug resistance in the region. In this review, we briefly discuss challenges of MDA, the use of MDA in the context of multidrug-resistant malaria, and the potential of different drug combinations and drug-based elimination strategies for mitigating the emergence and spread of resistance.

Keywords: drug resistance; malaria; mass drug administration.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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