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. 2018 Feb 27:5:41.
doi: 10.3389/fmed.2018.00041. eCollection 2018.

Telomerase Reverse Transcriptase Polymorphism rs2736100: A Balancing Act between Cancer and Non-Cancer Disease, a Meta-Analysis

Reinier Snetselaar  1 , Matthijs F M van Oosterhout  2 , Jan C Grutters  1   3 , Coline H M van Moorsel  1   3
Affiliations

Telomerase Reverse Transcriptase Polymorphism rs2736100: A Balancing Act between Cancer and Non-Cancer Disease, a Meta-Analysis

Reinier Snetselaar et al. Front Med (Lausanne). .

Abstract

The enzyme telomerase reverse transcriptase (TERT) is essential for telomere maintenance. In replicating cells, maintenance of telomere length is important for the preservation of vital genetic information and prevention of genomic instability. A common genetic variant in TERT, rs2736100 C/A, is associated with both telomere length and multiple diseases. Carriage of the C allele is associated with longer telomere length, while carriage of the A allele is associated with shorter telomere length. Furthermore, some diseases have a positive association with the C and some with the A allele. In this study, meta-analyses were performed for two groups of diseases, cancerous diseases, e.g., lung cancer and non-cancerous diseases, e.g., pulmonary fibrosis, using data from genome-wide association studies and case-control studies. In the meta-analysis it was found that cancer positively associated with the C allele (pooled OR 1.16 [95% CI 1.09-1.23]) and non-cancerous diseases negatively associated with the C allele (pooled OR 0.81 [95% CI 0.65-0.99]). This observation illustrates that the ambiguous role of telomere maintenance in disease hinges, at least in part, on a single locus in telomerase genes. The dual role of this single nucleotide polymorphism also emphasizes that therapeutic agents aimed at influencing telomere maintenance should be used with caution.

Keywords: cancer; degenerative disease; single nucleotide polymorphism; telomerase; telomere.

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Figures

Figure 1
Figure 1
Flowchart of studies included in the meta-analysis.
Figure 2
Figure 2
Meta-analysis of non-cancer association to rs2736100 allele C. OR, odds ratio; 95% CI, 95% confidence interval.
Figure 3
Figure 3
Meta-analysis of cancer association to rs2736100 allele C. OR, odds ratio; 95% CI, 95% confidence interval.
Figure 4
Figure 4
Overall association of the cancer and age-related group of diseases with telomerase reverse transcriptase rs2736100 allele C. OR, odds ratio; 95% CI, 95% confidence interval.
Figure 5
Figure 5
Evaluation of (publication) bias for the cancer (A) and non-cancer (B) meta-analysis. LFK index, Luis Furuya-Kanamori index; OR, odds ratio.
See this image and copyright information in PMC

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