The fibrinolytic enzyme system in normal menstruation and excessive uterine bleeding and the effect of tranexamic acid
- PMID: 2953634
- DOI: 10.1016/0028-2243(87)90156-0
The fibrinolytic enzyme system in normal menstruation and excessive uterine bleeding and the effect of tranexamic acid
Abstract
The fibrinolytic enzyme system of menstrual and peripheral blood was studied in three groups of women: Group 1, 20 subjects (mean age 37.2 years) with normal menstrual loss; Group 2, 20 patients (mean age 39 years) with dysfunctional uterine bleeding studied before treatment, and Group 3, during treatment with a fibrinolytic inhibitor, tranexamic acid (AMCA) (1 g 8-hourly). The fibrinolytic activity (plasminogen activator and plasmin) of menstrual blood was significantly higher than that of peripheral blood in the three groups (p less than 0.001). Both plasminogen activator and plasmin were higher in the menstrual blood of patients with menorrhagia (Group 2) compared with the control subjects (Group 1) (p less than 0.001 and p less than 0.1 respectively). Treatment with AMCA significantly reduced both plasminogen activator (p less than 0.01) and plasmin (p less than 0.05) in the menstrual blood of patients with menorrhagia (Group 3). No significant differences in fibrinolytic activity were found in peripheral blood between Groups 1 and 2; however, both plasminogen activator and plasmin were significantly lower (p less than 0.01) in Group 3 than in Group 2. Plasmin activity was also significantly lower (p less than 0.05) in Group 3 compared to Group 1. These findings confirm the presence of increased fibrinolytic activity in the uterus in excessive (dysfunctional) bleeding.
Similar articles
-
The effect of tranexamic acid on measured menstrual loss and endometrial fibrinolytic enzymes in dysfunctional uterine bleeding.Acta Obstet Gynecol Scand. 1994 Mar;73(3):274-7. doi: 10.3109/00016349409023453. Acta Obstet Gynecol Scand. 1994. PMID: 8122512
-
Endometrial fibrinolytic enzymes in women with normal menstruation and dysfunctional uterine bleeding.Br J Obstet Gynaecol. 1993 Aug;100(8):768-71. doi: 10.1111/j.1471-0528.1993.tb14272.x. Br J Obstet Gynaecol. 1993. PMID: 8399019
-
Treatment of menorrhagia during menstruation: randomised controlled trial of ethamsylate, mefenamic acid, and tranexamic acid.BMJ. 1996 Sep 7;313(7057):579-82. doi: 10.1136/bmj.313.7057.579. BMJ. 1996. PMID: 8806245 Free PMC article. Clinical Trial.
-
Tranexamic acid therapy for heavy menstrual bleeding.Expert Opin Pharmacother. 2011 Sep;12(13):2089-95. doi: 10.1517/14656566.2011.598857. Epub 2011 Jul 18. Expert Opin Pharmacother. 2011. PMID: 21767224 Review.
-
Tranexamic acid: a review of its use in the management of menorrhagia.Drugs. 2003;63(13):1417-33. doi: 10.2165/00003495-200363130-00008. Drugs. 2003. PMID: 12825966 Review.
Cited by
-
The role of blood in early endometrial-peritoneal interactions in a syngeneic mouse model of endometriosis.Reprod Med Biol. 2010 Sep 2;10(1):15-20. doi: 10.1007/s12522-010-0065-2. eCollection 2011 Mar. Reprod Med Biol. 2010. PMID: 29699078 Free PMC article.
-
Abnormal Uterine Bleeding in Young Women with Blood Disorders.Pediatr Clin North Am. 2018 Jun;65(3):543-560. doi: 10.1016/j.pcl.2018.02.008. Pediatr Clin North Am. 2018. PMID: 29803282 Free PMC article. Review.
-
Tranexamic acid: a review of its use in surgery and other indications.Drugs. 1999 Jun;57(6):1005-32. doi: 10.2165/00003495-199957060-00017. Drugs. 1999. PMID: 10400410 Review.
-
Medical management of menorrhagia.West J Med. 2000 Apr;172(4):253-5. doi: 10.1136/ewjm.172.4.253. West J Med. 2000. PMID: 18751263 Free PMC article. No abstract available.
-
Fortnightly review. Medical management of menorrhagia.BMJ. 1999 Nov 20;319(7221):1343-5. doi: 10.1136/bmj.319.7221.1343. BMJ. 1999. PMID: 10567142 Free PMC article. Review. No abstract available.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical