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. 2018 Apr;9(2):815-826.
doi: 10.1007/s13300-018-0401-9. Epub 2018 Mar 13.

Pioglitazone Improved Insulin Sensitivity and First Phase Insulin Secretion Among Obese and Lean People with Diabetes: A Multicenter Clamp Study

Xin Qian  1 , Hui Wang  1 , Gangyi Yang  2 , Zhengnan Gao  3 , Yong Luo  4 , Aimei Dong  5 , Fang Zhang  6 , Mingtong Xu  7 , Shiping Liu  8 , Xin Yang  9 , Yanyan Chen  1 , Guangwei Li  10
Affiliations

Pioglitazone Improved Insulin Sensitivity and First Phase Insulin Secretion Among Obese and Lean People with Diabetes: A Multicenter Clamp Study

Xin Qian et al. Diabetes Ther. 2018 Apr.

Abstract

Introduction: To investigate the effects of pioglitazone (PIO) on insulin resistance and first phase insulin secretion among obese and lean Chinese people with type 2 diabetes mellitus (T2DM).

Methods: Sixty-eight drug-naïve patients with T2DM were treated with PIO for 16 weeks. Before and after the treatment, insulin sensitivity was evaluated by the euglycemic hyperinsulinemic clamp test. Plasma insulin levels at 0, 3, 5, 7, and 10 min during intravenous glucose tolerance test were determined to calculate the first phase insulin secretion and pancreatic β-cell function. Circulating adiponectin levels were quantified.

Results: In both the lean and the obese patients with T2DM, the reduction of HbA1c following the PIO treatment was more than 1% (P < 0.001) and glucose infusion rate, acute insulin response, glucose disposal index, and β-cell glucose sensitivity increased significantly (P < 0.001). A multiple linear regression analysis showed that the improvements of first phase insulin secretion and insulin sensitivity were independently associated with the changes of HbA1c, but the change of first phase insulin secretion exhibited a higher correlation coefficient (R2 = 0.20, P = 0.001) than the change of insulin sensitivity did (R2 = 0.07, P = 0.040). The PIO treatment led to a significant increase in adiponectin levels only in the obese group (P < 0.05).

Conclusion: A 16-week treatment of PIO significantly increased insulin sensitivity and β-cell function in the lean group as well as in the obese group among Chinese T2DM patients, demonstrating that both lean and obese diabetic adults would profit from PIO.

Trial registration: The ChiCTR registry number is ChiCTR-OPC-17011571.

Funding: Takeda Pharmaceutical Co. Ltd. and Pfizer Pharmaceutical Co. Ltd.

Keywords: First phase; Insulin resistance; Insulin secretion; Pioglitazone.

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Figures

Fig. 1
Fig. 1
Plasma glucose changes after PIO treatment in the lean, obese, and whole groups. *P < 0.01 compare to the lean group
Fig. 2
Fig. 2
Glucose infusion rate (GIR), acute insulin response (AIR), and glucose disposal index (DI) before and after PIO treatment in the whole, lean, and obese groups. DI, the products of GIR and AIR
See this image and copyright information in PMC

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References

    1. Patel SA, Ali MK, Alam D, et al. Obesity and its relation with diabetes and hypertension: a cross-sectional study across 4 geographical regions. Glob Heart. 2016;11(1):71–79 e74. doi: 10.1016/j.gheart.2016.01.003. - DOI - PMC - PubMed
    1. Sondergaard E, Jensen MD. Quantification of adipose tissue insulin sensitivity. J Investig Med. 2016;64(5):989–91. - PubMed
    1. Zaccardi F, Webb DR, Yates T, Davies MJ. Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective. Postgrad Med J. 2016;1084(92):63–69. doi: 10.1136/postgradmedj-2015-133281. - DOI - PubMed
    1. Chen Y, Copeland WK, Vedanthan R, et al. Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium. BMJ. 2013;347:f5446. doi: 10.1136/bmj.f5446. - DOI - PMC - PubMed
    1. Ma RC, Chan JC. Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States. Ann N Y Acad Sci. 2013;1281:64–91. doi: 10.1111/nyas.12098. - DOI - PMC - PubMed

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