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. 1987 Apr;60(4):593-6.

Survival of deoxyguanosine-treated fetal thymus allografts is prevented by priming with dendritic cells

M T Benson, G Buckley, E J Jenkinson, J J Owen

Survival of deoxyguanosine-treated fetal thymus allografts is prevented by priming with dendritic cells

M T Benson et al. Immunology. 1987 Apr.

Abstract

Allogeneic thymus lobes rendered alymphoid by treatment with deoxyguanosine are not rejected in normal mice despite expression of class I and class II MHC antigens on donor cells. The results presented here show that the injection of as few as 10,000 cells from dendritic cell-enriched populations is followed by the rejection of deoxyguanosine-treated grafts. These findings support the notion that treated thymus grafts do not provoke rejection because they lack dendritic cells, which are destroyed by deoxyguanosine.

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