doi: 10.1038/327389a0.
Interaction of antibiotics with functional sites in 16S ribosomal RNA
- PMID: 2953976
- DOI: 10.1038/327389a0
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Interaction of antibiotics with functional sites in 16S ribosomal RNA
Nature.
1987 Jun.
Abstract
Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin and the neomycins) protect concise sets of highly conserved nucleotides in 16S ribosomal RNA when bound to ribosomes. These findings have strong implications for the mechanism of action of these antibiotics and for the assignment of functions to specific structural features of 16S rRNA.
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