[Drug nephrotoxicity]

Abstract

Drug-induced nephrotoxicity (DIN) remains a current problem with economic and medical consequences. It affects all nephron segments. Recovery of renal function is based on the identification of risk factors, early diagnosis of renal disease, rapid (if possible) cessation of the causative agent and, in some cases, adjunctive therapy. Prevention is based on identification of early markers of DIN, correction of risk factors, initial assessment of renal function for adequate dosage adjustment and exclusion of other nephrotoxic factors. It has recently been proposed to standardize the phenotype of iatrogenic renal disease and, on the other hand, new markers of renal toxicity allowing early diagnosis and therefore better management of nephrotoxicity.

Keywords: Acute interstitial nephritis; Acute kidney injury; Acute tubular necrosis; Drug nephrotoxicity; Glomerulopathy; Glomérulopathie; Lésions rénales aiguës; Microangiopathie thrombotique; Nécrose tubulaire aiguë; Néphrite interstitielle aiguë; Néphrotoxicité médicamenteuse; Thrombotic microangiopathy.