Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Feb 6:2018:5378284.
doi: 10.1155/2018/5378284. eCollection 2018.

The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response

Sabine Grösch  1 , Alice V Alessenko  2 , Elisabetta Albi  3
Affiliations
Review

The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response

Sabine Grösch et al. Mediators Inflamm. .

Abstract

This review provides an overview on components of the sphingolipid superfamily, on their localization and metabolism. Information about the sphingolipid biological activity in cell physiopathology is given. Recent studies highlight the role of sphingolipids in inflammatory process. We summarize the emerging data that support the different roles of the sphingolipid members in specific phases of inflammation: (1) migration of immune cells, (2) recognition of exogenous agents, and (3) activation/differentiation of immune cells.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Sphingolipid pathways. The de novo synthesis occurs in endoplasmic reticulum (ER). Other biochemical pathways occur in the plasma, lysosome, and nucleus membranes.
Figure 2
Figure 2
Activation, migration, and invasion of immune cells from the blood are influenced by several sphingolipids. (a) Initial adhesion step mediated by activation of immune cells by cytokines or chemokines and subsequent activation of integrins. (b) Activated integrins translocate into lipid rafts and bind to endothlial receptors like ICAM1. GluCer-enriched membranes are important for interaction with E-selectin. (c) Migration of immune cells is dependent on n-SMase and C1P.
See this image and copyright information in PMC

References

    1. Albi E., La Porta C. A. M., Cataldi S., Magni M. V. Nuclear sphingomyelin-synthase and protein kinase C δ in melanoma cells. Archives of Biochemistry and Biophysics. 2005;438(2):156–161. doi: 10.1016/j.abb.2005.04.004. - DOI - PubMed
    1. Albi E., Viola Magni M. P. The role of intranuclear lipids. Biology of the Cell. 2004;96(8):657–667. doi: 10.1016/j.biolcel.2004.05.004. - DOI - PubMed
    1. Albi E., Lazzarini R., Magni M. V. Reverse sphingomyelin-synthase in rat liver chromatin. FEBS Letters. 2003;549(1-3):152–156. doi: 10.1016/S0014-5793(03)00810-X. - DOI - PubMed
    1. Coant N., Sakamoto W., Mao C., Hannun Y. A. Ceramidases, roles in sphingolipid metabolism and in health and disease. Advances in Biological Regulation. 2017;63:122–131. doi: 10.1016/j.jbior.2016.10.002. - DOI - PMC - PubMed
    1. Kolesnick R. N., Hemer M. R. Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity. The Journal of Biological Chemistry. 1990;265(31):18803–18808. - PubMed

LinkOut - more resources