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Comment
. 2018 Feb 28:9:57.
doi: 10.3389/fendo.2018.00057. eCollection 2018.

Commentary: 3-Iodothyronamine Reduces Insulin Secretion In Vitro via a Mitochondrial Mechanism

Annunziatina Laurino  1 , Laura Raimondi  1
Affiliations
Comment

Commentary: 3-Iodothyronamine Reduces Insulin Secretion In Vitro via a Mitochondrial Mechanism

Annunziatina Laurino et al. Front Endocrinol (Lausanne). .
No abstract available

Keywords: 3-iodothyroacetic acid; 3-iodothyronamine; amine oxidase inhibitors; amine oxidases; diabetes; hyperglycemia.

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Figures

Figure 1
Figure 1
3-Iodothyronamine and hyperglycemia: the mediation of amine oxidases. 3-Iodothyronamine (T1AM) injected in mice induces hyperglycemia likely interacting at different pancreatic receptors promoting glucagon and reducing insulin release. At insulin-sensitive cells, including the pancreas, T1AM is converted into 3-iodotyroactic acid (TA1), the oxidative metabolite of T1AM by the activities of mitochondrial monoamine oxidase (MAOs), or semicarbazide-sensitive amine oxidases (SSAOs). TA1 can diffuse from cells and induce cell signaling activities and promoting hyperglycemia. The secondary product of amine oxidase activities, i.e., hydrogen peroxide (H2O2) and the aldehyde, may promote oxidative attack to cell components.
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