Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals

doi:10.2174/1874357901812010016

Review

. 2018 Feb 28:12:16-25.

doi: 10.2174/1874357901812010016. eCollection 2018.

Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals

Ivan Schietroma¹, Giuseppe Corano Scheri¹, Claudia Pinacchio¹, Maura Statzu², Arnolfo Petruzziello³, Vincenzo Vullo¹

Affiliations

¹ Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.
² Department of Molecular Medicine, Laboratory of Virology, "Sapienza" University of Rome, Rome, Italy.
³ Virology and Molecular Biology Unit, Department of Diagnostic Pathology, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy.

PMID: 29541275
PMCID: PMC5842384
DOI: 10.2174/1874357901812010016

Review

Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals

Ivan Schietroma et al. Open Virol J. 2018.

. 2018 Feb 28:12:16-25.

doi: 10.2174/1874357901812010016. eCollection 2018.

Authors

Ivan Schietroma¹, Giuseppe Corano Scheri¹, Claudia Pinacchio¹, Maura Statzu², Arnolfo Petruzziello³, Vincenzo Vullo¹

Affiliations

¹ Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.
² Department of Molecular Medicine, Laboratory of Virology, "Sapienza" University of Rome, Rome, Italy.
³ Virology and Molecular Biology Unit, Department of Diagnostic Pathology, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy.

PMID: 29541275
PMCID: PMC5842384
DOI: 10.2174/1874357901812010016

Abstract

Introduction: Globally, between 64 and 103 million people are chronically infected with Hepatitis C virus (HCV), with more than 4.6 million people in the United States and is associated with more than 15.000 deaths annually. Chronic infection can result in cirrhosis and hepatocellular carcinoma.

Explanation: Epidemiological studies have indicated that persistent infection with hepatitis C virus (HCV) is a major risk for the development of hepatocellular carcinoma (HCC), mainly through chronic inflammation, cell deaths, and proliferation. Despite the new direct-acting antiviral drugs (DAA's) being able to clear the HCV, HCC recurrence rate in these patients is still observed.

Conclusion: In this review we highlighted some aspects that could be involved in the onset of HCV-induced HCC such as immune system, viral factors and host genetics factors.Moreover, we focused on some of the last reports about the effects of DAA's on the HCV clearance and their potential implications in HCC recurrence.

Keywords: Chronic infection; DAA’s; HCC; HCV; Immunity; Viral factors.

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References

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[1] Chacko S., Samanta S. “Hepatocellular carcinoma: A life-threatening disease”. Biomed. Pharmacother. 2016;84:1679–1688. doi: 10.1016/j.biopha.2016.10.078. - DOI - PubMed

[2] Chacko S., Samanta S. “Hepatocellular carcinoma: A life-threatening disease”. Biomed. Pharmacother. 2016;84:1679–1688. doi: 10.1016/j.biopha.2016.10.078. - DOI - PubMed

[3] Elia G., Fallahi P. Hepatocellular carcinoma and CXCR3 chemokines: A narrative review. Clin. Ter. 2017;168(1):e37–e41. - PubMed

[4] Elia G., Fallahi P. Hepatocellular carcinoma and CXCR3 chemokines: A narrative review. Clin. Ter. 2017;168(1):e37–e41. - PubMed

[5] Balogh J., Victor D., III, Asham E.H., Burroughs S.G., Boktour M., Saharia A., Li X., Ghobrial R.M., Monsour H.P., Jr Hepatocellular carcinoma: A review. J Hepatocell Carcinoma. 2016;3:41–53. doi: 10.2147/JHC.S61146. - DOI - PMC - PubMed

[6] Balogh J., Victor D., III, Asham E.H., Burroughs S.G., Boktour M., Saharia A., Li X., Ghobrial R.M., Monsour H.P., Jr Hepatocellular carcinoma: A review. J Hepatocell Carcinoma. 2016;3:41–53. doi: 10.2147/JHC.S61146. - DOI - PMC - PubMed

[7] Nawaz R., Zahid S., Idrees M., Rafique S., Shahid M., Ahad A., Amin I., Almas I., Afzal S. HCV-induced regulatory alterations of IL-1β, IL-6, TNF-α, and IFN-ϒ operative, leading liver en-route to non-alcoholic steatohepatitis. Inflamm. Res. 2017;66(6):477–486. doi: 10.1007/s00011-017-1029-3. - DOI - PubMed

[8] Nawaz R., Zahid S., Idrees M., Rafique S., Shahid M., Ahad A., Amin I., Almas I., Afzal S. HCV-induced regulatory alterations of IL-1β, IL-6, TNF-α, and IFN-ϒ operative, leading liver en-route to non-alcoholic steatohepatitis. Inflamm. Res. 2017;66(6):477–486. doi: 10.1007/s00011-017-1029-3. - DOI - PubMed

[9] de Oliveria Andrade L.J., D’Oliveira A., Melo R.C., De Souza E.C., Costa Silva C.A., Paraná R. Association between hepatitis C and hepatocellular carcinoma. J. Glob. Infect. Dis. 2009;1(1):33–37. doi: 10.4103/0974-777X.52979. - DOI - PMC - PubMed

[10] de Oliveria Andrade L.J., D’Oliveira A., Melo R.C., De Souza E.C., Costa Silva C.A., Paraná R. Association between hepatitis C and hepatocellular carcinoma. J. Glob. Infect. Dis. 2009;1(1):33–37. doi: 10.4103/0974-777X.52979. - DOI - PMC - PubMed

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Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals

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Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals

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