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Review
. 2017 Dec 16;5(3):289-298.
doi: 10.1016/j.jcmgh.2017.12.004. eCollection 2018 Mar.

Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer

Leticia Moreira  1   2 , Basil Bakir  1 , Priya Chatterji  1 , Zahra Dantes  3 , Maximilian Reichert  3 , Anil K Rustgi  1
Affiliations
Review

Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer

Leticia Moreira et al. Cell Mol Gastroenterol Hepatol. .

Abstract

Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed appreciably. This review summarizes a rapidly emerging model of pancreatic cancer research, focusing on 3-dimensional organoids as a powerful tool for several applications, but above all, representing a step toward personalized medicine.

Keywords: 3D Organoids; 3D, 3-dimensional; Adenocarcinoma; GEMMs, genetically engineered mouse models; PDAC, pancreatic ductal adenocarcinoma; PDX, patient-derived tumor xenografts; PanIN, pancreatic intraepithelial neoplasia; Pancreas; Personalized Medicine.

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Figures

Figure 1
Figure 1
Three-dimensional organoids: generation and applications.
See this image and copyright information in PMC

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