The role of quantitative computed tomography in the diagnosis of chronic obstructive pulmonary disease

Abstract

In the last 25 years, there have been important improvements in computed tomography (CT) that may give more details about the lung structure in chronic obstructive pulmonary disease (COPD). The clinical exam and “classic” radiology (chest X-ray, conventional CT) have important roles: they raise the suspicion of hyperinflation, they highlight aspects of pulmonary hypertension, they may detect the triggers of exacerbations, they rule out some COPD complications and other lung diseases that can cause dyspnea (pneumothorax, tumors, bronchiectasis, and fibrosis). The spirometry may confirm the obstructive ventilatory disorder pattern of the disease. The modern CT scan technique - High Resolution CT (HRCT) with Multi-Detector CT procedure (MDCT) gives additional information about morphological details of parenchyma, bronchi, pulmonary vessels or lung function (ventilation/perfusion disorders) without significant lung irradiation. The new techniques provide quantifiable parameters that characterize the emphysema, the main COPD phenotypes and the risk of disease progression. Quantitative volumetric analysis of emphysema provides an early diagnosis of the disease in patients exposed to smoking and pollution. An early personalized diagnostic in COPD offers stronger reasons to prophylaxis by smoking and exposure cessation and an early targeted treatment (inhaled bronchodilators, anti-inflammatory medication, pulmonary rehabilitation, education for lifestyle changes).