[Imbalance of T lymphocyte subpopulations in patients with psoriasis and its immune correction]

Abstract

We investigated the levels of T-lymphocytes and their subpopulations-T-helper cells (TH) and T-suppressor cells (TS)-in the peripheral blood of 57 patients suffering from various clinical forms of psoriasis. Considerable decrease of the TH/TS rate (0.2 to 1.2) was found in 29 patients (15 with vulgar, 8 with arthropatic, and 6 with exudative psoriasis). The total number of T-lymphocytes was normal in 20 of these patients. In 8 patients showing a marked disbalance of TH and TS immunomodulators, thymalin and natrii nucleinas were included in the complex schedule of antipsoriatic therapy. As a result of the immunocorrective therapy, the disbalance normalized in 6 cases accompanied by regression of the psoriatic rash. The disbalance of TH and TS in the peripheral blood of the patients has a certain pathogenic significance in the development of psoriasis, and immunocorrection becomes necessary for successful therapy in severer forms of the disease.