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Review
. 2018 Apr;33(4):511-519.
doi: 10.1002/mds.27330. Epub 2018 Mar 15.

Initial cognitive changes in Parkinson's disease

Daniel Weintraub  1   2 , Alexander I Tröster  3 , Connie Marras  4 , Glenn Stebbins  5
Affiliations
Review

Initial cognitive changes in Parkinson's disease

Daniel Weintraub et al. Mov Disord. 2018 Apr.

Abstract

The focus on cognitive impairment in neurodegenerative diseases, including PD, is shifting from the dementia stage to earlier stages of impairment, including mild cognitive impairment. This shift is driven primarily by the desire to improve long-term outcomes by delivering therapeutic interventions earlier in the clinical course, even presymptomatically in those at highest risk, and at the initial stage in the pathophysiological cascade that underpins common dementia syndromes. This article focuses on key findings and challenges in studying earliest stages of cognitive decline in PD, including a detailed examination of neuropsychological testing, cognitive performance in early and prodromal PD, epidemiological research for PD mild cognitive impairment to date, and expert recommendations for assessment. © 2018 International Parkinson and Movement Disorder Society.

Keywords: Parkinson's disease; dementia; mild cognitive impairment; neuropsychological testing.

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Conflict of interest statement

Conflicts of interest: The authors report no conflict of interest for this manuscript.

References

    1. Marras C, Troster AI, Kulisevsky J, Stebbins GT. The tools of the trade: a state of the art “How to Assess Cognition” in the patient with Parkinson’s disease. Mov Disord. 2014;29:584–596. - PubMed
    1. Litvan I, Goldman J, Troster A, et al. Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society Task Force Guidelines. Movement Disorders. 2012;27:349–356. - PMC - PubMed
    1. Benge JF, Balsis S, Madeka T, Uhlman C, Lantrip C, Soileau MJ. Factor structure of the Montreal Cognitive Assessment items in a sample with early Parkinson’s disease. Parkinsonism Relat Disord. 2017;41:104–108. - PubMed
    1. Troster AI, Jankovic J, Tagliati M, Peichel D, Okun MS. Neuropsychological outcomes from constant current deep brain stimulation for Parkinson’s disease. Mov Disord. 2017;32:433–440. - PMC - PubMed
    1. Lawson RA, Yarnall AJ, Duncan GW, et al. Severity of mild cognitive impairment in early Parkinson’s disease contributes to poorer quality of life. Parkinsonism Relat Disord. 2014;20:1071–1075. - PMC - PubMed

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