Review

. 2018 Mar 15;15(1):7.

doi: 10.1186/s12981-018-0194-y.

Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells

Rose Nabatanzi¹, Stephen Cose², Moses Joloba³, Sarah Rowland Jones⁴, Damalie Nakanjako^{5

6}

Affiliations

¹ Department of Immunology and Molecular Biology, Makerere University College of Health Sciences, P. O. Box 7072, Kampala, Uganda. rosemagala@gmail.com.
² MRC/UVRI Uganda Research Unit on AIDS and London School of Hygiene & Tropical Medicine, London, UK.
³ Department of Immunology and Molecular Biology, Makerere University College of Health Sciences, P. O. Box 7072, Kampala, Uganda.
⁴ Nuffield Department of Medicine, University of Oxford, Oxford, UK.
⁵ Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
⁶ Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda.

PMID: 29544508
PMCID: PMC5853105
DOI: 10.1186/s12981-018-0194-y

Review

Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells

Rose Nabatanzi et al. AIDS Res Ther. 2018.

. 2018 Mar 15;15(1):7.

doi: 10.1186/s12981-018-0194-y.

Authors

Rose Nabatanzi¹, Stephen Cose², Moses Joloba³, Sarah Rowland Jones⁴, Damalie Nakanjako^{5

6}

Affiliations

¹ Department of Immunology and Molecular Biology, Makerere University College of Health Sciences, P. O. Box 7072, Kampala, Uganda. rosemagala@gmail.com.
² MRC/UVRI Uganda Research Unit on AIDS and London School of Hygiene & Tropical Medicine, London, UK.
³ Department of Immunology and Molecular Biology, Makerere University College of Health Sciences, P. O. Box 7072, Kampala, Uganda.
⁴ Nuffield Department of Medicine, University of Oxford, Oxford, UK.
⁵ Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
⁶ Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda.

PMID: 29544508
PMCID: PMC5853105
DOI: 10.1186/s12981-018-0194-y

Abstract

HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (ILCs). Although antiretroviral therapy (ART) restores CD4 T-cell counts, the persistent aberrant activation of monocytes, NK and ILCs observed likely contributes to the incomplete recovery of T-cell effector functions. A better understanding of the effects of HIV infection and ART on the phenotype and function of circulating monocytes, NK, and ILCs is required to guide development of novel therapeutic interventions to optimize immune recovery.

Keywords: Antiretroviral therapy; HIV; Innate immunity; Innate lymphoid cells; Monocytes; Natural killer cells.

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Figures

**Fig. 1**
The effects of HIV infection and ART on monocytes, NK cells, ILCs

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Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells

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