Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May-Jun;59(3):220-226.
doi: 10.1016/j.psym.2018.01.011. Epub 2018 Feb 2.

Psychiatric Illness in Takotsubo (Stress) Cardiomyopathy: A Review

Arash Nayeri  1 , Eric Rafla-Yuan  2 , Srikanth Krishnan  3 , Boback Ziaeian  3 , Martin Cadeiras  3 , John A McPherson  4 , Quinn S Wells  4
Affiliations
Review

Psychiatric Illness in Takotsubo (Stress) Cardiomyopathy: A Review

Arash Nayeri et al. Psychosomatics. 2018 May-Jun.

Abstract

Background: Takotsubo cardiomyopathy (TC), also known as stress-induced cardiomyopathy, has been increasingly described in relation to psychiatric illness.

Methods: We performed a literature review to identify the key findings related to psychiatric illness in TC that may be relevant to the practice of mental health and other health care providers.

Results: The association of psychiatric illness with TC in addition to the spectrum of psychiatric illness found in TC, the role of exacerbation or treatment of psychiatric illness in triggering TC, different modes of presentation, prognostic implications, and long-term management of psychiatric illness in TC are discussed. Additionally, we review the limitations of the pre-existing literature and suggest areas of future research.

Conclusions: There is a strong association between pre-existing psychiatric illness, particularly anxiety and mood spectrum disorders, and TC. Acute exacerbation of psychiatric illness, rapid uptitration or overdose of certain psychotropic agents, and electroconvulsive therapy may trigger TC. Further studies are needed to better evaluate the prognostic significance and long-term management of psychiatric illness in TC.

Keywords: Takotsubo; anxiety; depression; psychiatric illness; stress cardiomyopathy.

PubMed Disclaimer

Figures

FIGURE 1.
FIGURE 1.
Spectrum of Pre-existing Psychiatric Illness in TC (Borrowed, With Permission, From the Original Source).
FIGURE 2.
FIGURE 2.
Mode of TC Trigger. Percent of Cases Triggered By Physical vs Nonphysical (Including Emotional) Stressors Are Shown.
See this image and copyright information in PMC

References

    1. Khera R, Light-mcgroary K, Zahr F, Horwitz PA, Girotra S: Trends in hospitalization for takotsubo cardiomyopathy in the United States. Am Heart J 2016; 172:53–63 - PMC - PubMed
    1. Prasad A, Lerman A, Rihal CS: Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J 2008; 155(3):408–417 - PubMed
    1. Templin C, Ghadri JR, Diekmann J, et al.: Clinical features and outcomes of Takotsubo (Stress) Cardiomyopathy. N Engl J Med 2015; 373(10):929–938 - PubMed
    1. Nayeri A, Rafla-yuan E, Farber-eger E, et al.: Pre-existing psychiatric illness is associated with increased risk of recurrent Takotsubo cardiomyopathy. Psychosomatics. 2017; 58:527–532 - PMC - PubMed
    1. El-sayed AM, Brinjikji W, Salka S: Demographic and comorbid predictors of stress (Takotsubo) cardiomyopathy. Am J Cardiol 2012; 110(9):1368–1372 - PubMed

MeSH terms

Substances