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. 2018 Sep;103(9):e404-e407.
doi: 10.3324/haematol.2018.188094. Epub 2018 Mar 15.

Efficacy of the combination of venetoclax and hypomethylating agents in relapsed/refractory acute myeloid leukemia

Affiliations

Efficacy of the combination of venetoclax and hypomethylating agents in relapsed/refractory acute myeloid leukemia

Ibrahim Aldoss et al. Haematologica. 2018 Sep.
No abstract available

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Figures

Figure 1.
Figure 1.
Survival of refractory/relapsed acute myeloid leukemia (AML) after hypomethylating agent and venetoclax therapy. (A) Overall survival and (B) leukemia-free survival (LFS).

References

    1. Konopleva M, Pollyea DA, Potluri J, et al. Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia. Cancer Discov. 2016;6(10):1106–1117. - PMC - PubMed
    1. Kumar S, Kaufman JL, Gasparetto C, et al. Efficacy of venetoclax as targeted therapy for relapsed/refractory t(11;14) multiple myeloma. Blood. 2017;130(22):2401–2409. - PubMed
    1. Roberts AW, Davids MS, Pagel JM, et al. Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia. N Engl J Med. 2016;374(4):311–22. - PMC - PubMed
    1. Lagadinou ED, Sach A, Callahan K, et al. BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell. 2013;12(3):329–341. - PMC - PubMed
    1. Bogenberger JM, Kornblau SM, Pierceall WE, et al. BCL-2 family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies. Leukemia. 2014;28(8):1657–1665. - PMC - PubMed

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