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. 2017 Nov 20:41:461-464.
doi: 10.1016/j.ijscr.2017.11.024. eCollection 2017.

A novel haemostatic agent based on self-assembling peptides in the setting of nasal endoscopic surgery, a case series

M F Lee  1 , Z Ma  2 , A Ananda  3
Affiliations

A novel haemostatic agent based on self-assembling peptides in the setting of nasal endoscopic surgery, a case series

M F Lee et al. Int J Surg Case Rep. .

Abstract

Introduction: Recently, a novel purely synthetic topical haemostatic agent (PuraStat®) has been proposed in surgery based on the self-assembling tendency of some repeating peptide sequences. This transparent, ready to use hydrogel appears suitable for use in FEES with low rates of post-operative re-bleeding and adhesion formation.A first series of 60 patients experiencing endonasal powered turbinoplasty across various hospitals in Sydney using PuraStat® was observed for postoperative re-bleeding and adhesion formation.

Discussion: In all 60 patients, no post-operative re-bleeding was observed, while healing went well in absence of adhesion formation. Effective haemostasis with PuraStat® is well documented in other surgical fields, but its use in FEES and adhesion prevention is relatively novel.

Conclusion: Synthetic self-assembling peptides appear to be indicated in this area. Further studies are needed to confirm their potential for adhesion prevention.

Keywords: Endonasal surgery; Endoscopic nasal surgery; Endoscopic turbinoplasty; FEES, Functional Endoscopic Endonasal Surgery; Haemostasis; PuraStat; RADA, short peptide made of 4 amino acids (Arginine-Alanine-Aspartic acid-Alanine) repeated 4 times.

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Figures

Fig. 1
Fig. 1
PuraStat® peptide hydrogel.
Fig. 2
Fig. 2
Application of PuraStat® in endoscopic inferior turbinoplasty.
Fig. 3
Fig. 3
Video displaying use of PuraStat® in ENT surgery.
See this image and copyright information in PMC

References

    1. Agha R.A., Fowler A.J., Rammohan S., Barai I., Orgill D.P., the PROCESS Group The process statement: preferred reporting of case series in surgery. Int. J. Surg. 2016;36(Pt A):319–323. - PubMed
    1. Zhang S. Fabrication of novel biomaterials through molecular self-assembly. Nat. Biotechnol. 2003;21(10):1171–1178. - PubMed
    1. Zhao X., Pan F., Lu J.R. Recent development of peptide self-assembly. Prog. Nat. Sci. 2008;18:653–660.
    1. Uraoka T., Ochiai Y., Fujimoto A., Goto O., Kawahara Y., Kobayashi N., Kanai T., Matsuda S., Kitagawa Y., Yahagi N. A novel fully synthetic and self-assembled peptide solution for endoscopic submucosal dissection-induced ulcer in the stomach. Gastrointest. Endosc. 2016;83(June (6)):1259–1264. - PubMed
    1. Masuhara H., Fujii T., Watanabe Y., Koyama N., Tokuhiro K. Novel infectious agent-free hemostatic material (TDM-621) in cardiovascular surgery. Ann. Thorac. Cardiovasc. Surg. 2012;18(5):444–451. - PubMed