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Comment
. 2018 May;14(5):254-255.
doi: 10.1038/nrendo.2018.31. Epub 2018 Mar 16.

Bone: Bone marrow adipocytes in 3D

Kenneth T Lewis  1 , Ormond A MacDougald  2   1
Affiliations
Comment

Bone: Bone marrow adipocytes in 3D

Kenneth T Lewis et al. Nat Rev Endocrinol. 2018 May.

Abstract

Culturing bone marrow stromal cells on 3D silk scaffolds supports their proliferation and adipogenesis, while minimizing the activation of inflammatory pathways. Therefore, differentiation of bone marrow adipocytes in 3D culture might provide a more representative model for the study of bone marrow adipose tissue than is offered by traditional 2D cell cultures.

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Conflict of interest statement

Competing interests statement

The authors declare no competing interests.

Comment on

  • Development of a 3D bone marrow adipose tissue model.
    Fairfield H, Falank C, Farrell M, Vary C, Boucher JM, Driscoll H, Liaw L, Rosen CJ, Reagan MR. Fairfield H, et al. Bone. 2019 Jan;118:77-88. doi: 10.1016/j.bone.2018.01.023. Epub 2018 Jan 31. Bone. 2019. PMID: 29366838 Free PMC article.

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