Fungal Secretion: The Next-Gen Target of Antifungal Agents?

Julianne Teresa Djordjevic¹, Sophie Lev²

Affiliations

¹ Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, 176 Hawkesbury Road, Westmead, NSW 2145, Australia; Sydney Medical School - Westmead, University of Sydney, Westmead, NSW 2145, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, NSW, Australia. Electronic address: julianne.djordjevic@sydney.edu.au.
² Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, 176 Hawkesbury Road, Westmead, NSW 2145, Australia; Sydney Medical School - Westmead, University of Sydney, Westmead, NSW 2145, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, NSW, Australia.

PMID: 29547713
DOI: 10.1016/j.chembiol.2018.02.015

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Fungal Secretion: The Next-Gen Target of Antifungal Agents?

Julianne Teresa Djordjevic et al. Cell Chem Biol. 2018.

Free article

. 2018 Mar 15;25(3):233-235.

doi: 10.1016/j.chembiol.2018.02.015.

Authors

Julianne Teresa Djordjevic¹, Sophie Lev²

Affiliations

¹ Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, 176 Hawkesbury Road, Westmead, NSW 2145, Australia; Sydney Medical School - Westmead, University of Sydney, Westmead, NSW 2145, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, NSW, Australia. Electronic address: julianne.djordjevic@sydney.edu.au.
² Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, 176 Hawkesbury Road, Westmead, NSW 2145, Australia; Sydney Medical School - Westmead, University of Sydney, Westmead, NSW 2145, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, NSW, Australia.

PMID: 29547713
DOI: 10.1016/j.chembiol.2018.02.015

Abstract

Invasive fungal diseases pose a serious threat, and new drugs are urgently needed. In this issue of Cell Chemical Biology, Pries et al. (2018) identified benzamide- and picolinamide-based small-molecule inhibitors with antifungal properties, including some active against pathogenic Candida species. These compounds target an essential component of the fungal secretion machinery, suggesting a new approach to antifungal development.

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Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.
Pries V, Nöcker C, Khan D, Johnen P, Hong Z, Tripathi A, Keller AL, Fitz M, Perruccio F, Filipuzzi I, Thavam S, Aust T, Riedl R, Ziegler S, Bono F, Schaaf G, Bankaitis VA, Waldmann H, Hoepfner D. Pries V, et al. Cell Chem Biol. 2018 Mar 15;25(3):279-290.e7. doi: 10.1016/j.chembiol.2017.12.007. Epub 2018 Jan 4. Cell Chem Biol. 2018. PMID: 29307839 Free PMC article.

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Fungal Secretion: The Next-Gen Target of Antifungal Agents?

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Fungal Secretion: The Next-Gen Target of Antifungal Agents?

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