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Review
. 2018 Apr:124:37-40.
doi: 10.1016/j.critrevonc.2018.02.004. Epub 2018 Feb 7.

Mathematical modeling of cancer metabolism

Miguel Ángel Medina  1
Affiliations
Free article
Review

Mathematical modeling of cancer metabolism

Miguel Ángel Medina. Crit Rev Oncol Hematol. 2018 Apr.
Free article

Abstract

Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential hallmark of cancer. Mathematical modeling could contribute to a better understanding of cancer metabolic reprogramming and to identify new potential ways of therapeutic intervention. Herein, I review several alternative approaches to metabolic modeling and their current and future impact in oncology.

Keywords: Cancer; Mathematical model; Metabolism; Systems biology; Tumor microenvironment.

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