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Comment
. 2019 Feb;68(2):378-380.
doi: 10.1136/gutjnl-2017-315560. Epub 2018 Mar 16.

Hypertriglyceridaemia delays pancreatic regeneration after acute pancreatitis in mice and patients

Na Yang #  1 , Baiqiang Li #  1 , Yiyuan Pan #  1   2 , Jianfeng Tu  1 , George Liu  3 , Guotao Lu  1   4 , Weiqin Li  1
Affiliations
Comment

Hypertriglyceridaemia delays pancreatic regeneration after acute pancreatitis in mice and patients

Na Yang et al. Gut. 2019 Feb.
No abstract available

Keywords: acute pancreatitis; cell proliferation; lipids.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
HTG inhibits pancreatic repair after caerulein-induced AP. (A) Representative histological changes in the pancreas of the P407-AP group (the HTG mice) and the phosphate buffer saline (PBS)-AP group (the NTG mice). HTG was induced using 0.5 g/kg P407 in the P407-AP group. The PBS-AP group was administered PBS instead of P407 in the same amount and duration. Scale bar: 50 µm. (B) Representative histological changes in the pancreas of the GPIHBP1−/−-AP group (the HTG mice) and the WT-AP group (the NTG mice). Scale bar: 50 µm. (C) Quantification of the necrotic area as a percentage of the total pancreatic sections at different time points (n=10 per group). *P<0.05, **P<0.01, ***P<0.001 vs control group; #P<0.05, ##P<0.01 vs prior time points. (D) Comparison of the FE-1 levels between the HTG categories in the patients with severe AP (n=11 for NTG, n=37 for mild HTG, n=11 for moderate HTG and n=14 for severe HTG). *One-way ANOVA for the trend was significant. #The Bonferroni test for post hoc analysis was significant. AP, acute pancreatitis; FE-1, faecal elastase 1; GPIHBP1, glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein1; HTG, hypertriglyceridaemia; NTG, normal triglyceride; P407, poloxamer 407; WT, wild type.
Figure 2
Figure 2
Fenofibrate promotes pancreatic recovery in HTG mice after caerulein-induced AP. HTG was induced using 0.5 g/kg P407 in the P407-AP group. (A) Timetable of fenofibrate administration (100 mg/kg/three times a day by gavage 6 hours after the initial injection of caerulein). (B) Serum TG and TC levels of HTG mice at different time points after AP induction (n=10 per group). (C) Quantification of the necrotic area as a percentage of the total pancreatic sections after AP induction (n=10 per group). (D) Representative histological changes in the pancreas. Scale bar: 50 µm. *P<0.05, **P<0.01, ***P<0.001 vs control group; #P<0.05, ##P<0.01 vs prior time points. AP, acute pancreatitis; GPIHBP1, glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein1; HTG, hypertriglyceridaemia; P407, poloxamer 407; TC, total cholesterol; TG, triglyceride.
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