Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Mar 16;8(1):4728.
doi: 10.1038/s41598-018-22904-7.

Association between Thyroid Hormone Levels and Diabetic Kidney Disease in Euthyroid Patients with Type 2 Diabetes

Jian Zou  1   2 , Feng Tian  1 , Yi Zhang  2   3 , Zeping Li  4 , Chao Yang  5 , Haixu Chen  6 , Jiajia Zhai  2 , Min Shi  2 , Chao Xu  1 , Juan Zhang  7 , Wenjuan Li  2 , Yonghong Xie  8 , Xiaomiao Li  9
Affiliations

Association between Thyroid Hormone Levels and Diabetic Kidney Disease in Euthyroid Patients with Type 2 Diabetes

Jian Zou et al. Sci Rep. .

Abstract

The association between normal thyroid function and diabetic kidney disease (DKD) has gained increasing attention. The present study evaluated the relationship between normal thyroid hormone levels and DKD in type 2 diabetes mellitus (T2DM) patients. A total of 862 type 2 diabetes patients were enrolled in this cross-sectional study in Xi'an, Shaanxi Province, China. The subjects were evaluated for anthropometric measurements, thyroid function and DKD. Of 862 patients, 246 (28.5%) suffered from DKD, and the prevalence of DKD did not differ between men and women. The prevalence of DKD showed a significantly decreasing trend across the quartiles based on free triiodothyronine (FT3) levels (41.1%, 30.6%, 23.8%, and 18.9%, P < 0.001). In comparison with all participants categorized in the first FT3 quartile group (FT3-Q1) (<4.380), the adjusted odds ratio of DKD in the second FT3 quartile group (FT3-Q2), the third FT3 quartile group (FT3-Q3), and the fourth FT3 quartile group (FT3-Q4) were 0.655(95%CI: 0.406-1.057), 0.493(95%CI: 0.299-0.813), 0.406(0.237-0.697) (P < 0.05). Also, similar results were observed in men. Conversely, none of the FT3 groups was associated with DKD in women. The present study showed that FT3 within normal range was negatively correlated with DKD in T2DM patients.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Prevalence of DKD among quartiles based on FT3 and FT4 (*p < 0.05, ***p < 0.001) Q1: the first FT3 (FT4) quartile group, Q2: the second FT3 (FT4) quartile group, Q3: the third FT3 (FT4) quartile group, Q4: the fourth FT3 (FT4) quartile group.
Figure 2
Figure 2
Prevalence of DKD among groups based on TSH levels and TPO-Ab. TSH1: <2.5 μIU/mL, TSH2 ≥2.5 μIU/mL, TPO-Ab1 < 78 U/mL, TPO-Ab2 ≥ 78 U/ml).
See this image and copyright information in PMC

References

    1. Molitch ME, et al. Nephropathy in diabetes. Diabetes care. 2004;27(Suppl 1):S79–83. - PubMed
    1. Wu P. Thyroid disorders and diabetes. It is common for a person to be affected by both thyroid disease and diabetes. Diabetes self-management. 2007;24(80–82):85–87. - PubMed
    1. Furukawa S, et al. Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus. Endocrine journal. 2014;61:1011–1018. doi: 10.1507/endocrj.EJ14-0206. - DOI - PubMed
    1. Chen HS, et al. Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients. Diabetic medicine: a journal of the British Diabetic Association. 2007;24:1336–1344. doi: 10.1111/j.1464-5491.2007.02270.x. - DOI - PubMed
    1. Yasuda T, et al. Subclinical hypothyroidism is independently associated with albuminuria in people with type 2 diabetes. Diabetes research and clinical practice. 2011;94:e75–77. doi: 10.1016/j.diabres.2011.08.019. - DOI - PubMed

Publication types