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Review
. 2017:1053:221-243.
doi: 10.1007/978-3-319-72077-7_11.

Computer-Aided Antibody Design: An Overview

Yee Siew Choong  1 , Yie Vern Lee  2 , Jia Xin Soong  2 , Cheh Tat Law  2 , Yee Ying Lim  2
Affiliations
Review

Computer-Aided Antibody Design: An Overview

Yee Siew Choong et al. Adv Exp Med Biol. 2017.

Abstract

The use of monoclonal antibody as the next generation protein therapeutics with remarkable success has surged the development of antibody engineering to design molecules for optimizing affinity, better efficacy, greater safety and therapeutic function. Therefore, computational methods have become increasingly important to generate hypotheses, interpret and guide experimental works. In this chapter, we discussed the overall antibody design by computational approches.

Keywords: Antibody design; Computational tools; Docking; In silico; Modelling; ab initio.

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