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. 2018 May:196:168-174.e1.
doi: 10.1016/j.jpeds.2018.01.028. Epub 2018 Mar 15.

Validity of Body Mass Index as a Measure of Adiposity in Infancy

Katherine A Bell  1 , Carol L Wagner  2 , Wei Perng  3 , Henry A Feldman  4 , Roman J Shypailo  5 , Mandy B Belfort  6
Affiliations

Validity of Body Mass Index as a Measure of Adiposity in Infancy

Katherine A Bell et al. J Pediatr. 2018 May.

Abstract

Objectives: To assess the validity of body mass index (BMI) and age- and sex-standardized BMI z-score (BMIZ) as surrogates for adiposity (body fat percentage [BF%], fat mass, and fat mass index [kg/m2]) at 3 time points in infancy (1, 4, and 7 months) and to assess the extent to which the change in BMIZ represents change in adiposity.

Study design: We performed a secondary analysis of 447 full-term infants in a previous trial of maternal vitamin D supplementation during lactation. Study staff measured infant anthropometrics and assessed body composition with dual-energy x-ray absorptiometry at 1, 4, and 7 months of age. We calculated Spearman correlations (rs) among BMI, BMIZ, and adiposity at each time point, and between change in BMIZ and change in adiposity between time points.

Results: Infants (N = 447) were 52% male, 38% white, 31% black, and 29% Hispanic. The BMIZ was moderately correlated with BF% (rs = 0.43, 0.55, 0.48 at 1, 4, and 7 months of age, respectively). BMIZ correlated more strongly with fat mass and fat mass index, particularly at 4 and 7 months of age (fat mass rs = 0.72-0.76; fat mass index rs = 0.75-0.79). Changes in BMIZ were moderately correlated with adiposity changes from 1 to 4 months of age (rs = 0.44 with BF% change; rs = 0.53 with fat mass change), but only weakly correlated from 4 to 7 months of age (rs = 0.21 with BF% change; rs = 0.27 with fat mass change).

Conclusions: BMIZ is moderately correlated with adiposity in infancy. Changes in BMIZ are a poor indicator of adiposity changes in later infancy. BMI and BMIZ are limited as surrogates for adiposity and especially adiposity changes in infancy.

Trial registration: ClinicalTrials.gov: NCT00412074.

Keywords: body composition; infant.

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Figures

Figure 1
Figure 1
Participant flow diagram.
Figure 2
Figure 2
Scatterplots of body fat percentage and BMI z-score in full term infants at 1 month (panel A; N=437), 4 months (panel B; N=331), and 7 months (panel C; N=277).
See this image and copyright information in PMC

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