Bronchopulmonary Dysplasia: Executive Summary of a Workshop

Rosemary D Higgins¹, Alan H Jobe², Marion Koso-Thomas³, Eduardo Bancalari⁴, Rose M Viscardi⁵, Tina V Hartert⁶, Rita M Ryan⁷, Suhas G Kallapur⁸, Robin H Steinhorn⁹, Girija G Konduri¹⁰, Stephanie D Davis¹¹, Bernard Thebaud¹², Ronald I Clyman¹³, Joseph M Collaco¹⁴, Camilia R Martin¹⁵, Jason C Woods¹⁶, Neil N Finer¹⁷, Tonse N K Raju³

Affiliations

¹ Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD. Electronic address: higginsr@mail.nih.gov.
² Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
³ Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD.
⁴ Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL.
⁵ Department of Pediatrics, University of Maryland Baltimore, Baltimore, MD.
⁶ Department of Medicine, Division of Allergy, Pulmonology and Critical Care Medicine, Vanderbilt University, Nashville, TN.
⁷ Department of Pediatrics, Medical University of South Carolina, Charleston, SC.
⁸ Divisions of Neonatology and Developmental Biology Professor of Pediatrics David Geffen School of Medicine at UCLA Mattel Children's Hospital UCLA, Los Angeles, CA.
⁹ Children's National Health System, Department of Pediatrics, Washington, DC.
¹⁰ Department of Pediatrics, Cardiovascular Research Center and Children's Research Institute, Medical College of Wisconsin, Milwaukee, WI.
¹¹ Section of Pediatric Pulmonology, Allergy and Sleep Medicine, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.
¹² Department of Pediatrics, Children's Hospital of Eastern Ontario and Children's Hospital of Ontario Research Institute (CHEORI), Ontario, Canada; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute (OHRI), Ontario, Canada; Department of Cellular and Molecular Biology, University of Ottawa, Ontario, Canada.
¹³ Department of Pediatrics, University of California, San Francisco, San Francisco, CA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA.
¹⁴ Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, MD.
¹⁵ Department of Neonatology and Division of Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
¹⁶ Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
¹⁷ Department of Pediatrics, University of California at San Diego, San Diego, CA.

PMID: 29551318
PMCID: PMC5970962
DOI: 10.1016/j.jpeds.2018.01.043

Bronchopulmonary Dysplasia: Executive Summary of a Workshop

Rosemary D Higgins et al. J Pediatr. 2018 Jun.

. 2018 Jun:197:300-308.

doi: 10.1016/j.jpeds.2018.01.043. Epub 2018 Mar 16.

Authors

Affiliations

¹ Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD. Electronic address: higginsr@mail.nih.gov.
² Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
³ Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD.
⁴ Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL.
⁵ Department of Pediatrics, University of Maryland Baltimore, Baltimore, MD.
⁶ Department of Medicine, Division of Allergy, Pulmonology and Critical Care Medicine, Vanderbilt University, Nashville, TN.
⁷ Department of Pediatrics, Medical University of South Carolina, Charleston, SC.
⁸ Divisions of Neonatology and Developmental Biology Professor of Pediatrics David Geffen School of Medicine at UCLA Mattel Children's Hospital UCLA, Los Angeles, CA.
⁹ Children's National Health System, Department of Pediatrics, Washington, DC.
¹⁰ Department of Pediatrics, Cardiovascular Research Center and Children's Research Institute, Medical College of Wisconsin, Milwaukee, WI.
¹¹ Section of Pediatric Pulmonology, Allergy and Sleep Medicine, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.
¹² Department of Pediatrics, Children's Hospital of Eastern Ontario and Children's Hospital of Ontario Research Institute (CHEORI), Ontario, Canada; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute (OHRI), Ontario, Canada; Department of Cellular and Molecular Biology, University of Ottawa, Ontario, Canada.
¹³ Department of Pediatrics, University of California, San Francisco, San Francisco, CA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA.
¹⁴ Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, MD.
¹⁵ Department of Neonatology and Division of Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
¹⁶ Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
¹⁷ Department of Pediatrics, University of California at San Diego, San Diego, CA.

PMID: 29551318
PMCID: PMC5970962
DOI: 10.1016/j.jpeds.2018.01.043

No abstract available

Keywords: bronchopulmonary dysplasia; infant; oxygen; premature; ventilation.

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Figures

**Figure**
Multifactorial etiology of BPD: different antenatal and postnatal factors contribute to BPD. The clinical phenotypes and severity of BPD can vary between subjects with variable contributions from parenchymal lung disease, airway disease, or pulmonary vascular disease. The degree of prematurity is the most important predisposing factor.

See this image and copyright information in PMC

Comment in

Bronchopulmonary Dysplasia: The Ongoing Search for One Definition to Rule Them All.
Jensen EA, Wright CJ. Jensen EA, et al. J Pediatr. 2018 Jun;197:8-10. doi: 10.1016/j.jpeds.2018.02.047. Epub 2018 Mar 28. J Pediatr. 2018. PMID: 29605396 No abstract available.
Midlife crisis? In its 50th year, BPD redefines itself.
Wright CJ. Wright CJ. J Pediatr. 2018 Jun;197:3. doi: 10.1016/j.jpeds.2018.04.017. J Pediatr. 2018. PMID: 29801543 No abstract available.
Contingencies on the workshop for bronchopulmonary dysplasia classification.
Aly H, Mohamed MA, Wung JT. Aly H, et al. J Pediatr. 2019 Apr;207:263-264. doi: 10.1016/j.jpeds.2018.11.055. Epub 2018 Dec 24. J Pediatr. 2019. PMID: 30587421 No abstract available.
Reply.
Higgins RD, Jobe AH. Higgins RD, et al. J Pediatr. 2019 Apr;207:264. doi: 10.1016/j.jpeds.2018.11.056. Epub 2018 Dec 24. J Pediatr. 2019. PMID: 30591266 Free PMC article. No abstract available.

References

1. Northway WH, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease, bronchopulmonary dysplasia. N Engl J Med. 1967;276:357–68. - PubMed
1. Philip AG. Oxygen plus pressure plus time: the etiology of bronchopulmonary dysplasia. Pediatrics. 1975;55:44–50. - PubMed
1. Durang M, Rigatto H. Tidal volume and respiratory frequency in infants with bronchopulmonary dysplasia (BPD) Early Hum Dev. 1981;5:55–62. - PubMed
1. Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM. Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics. 1988;82:527–32. - PubMed
1. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723–9. - PubMed

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Bronchopulmonary Dysplasia: Executive Summary of a Workshop

Affiliations

Bronchopulmonary Dysplasia: Executive Summary of a Workshop

Authors

Affiliations

Figures

Comment in

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical