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. 2017 Nov-Dec;21(6):449-455.
doi: 10.4103/jisp.jisp_107_17.

Evaluation of peripheral neutrophil functions in aggressive periodontitis patients and their family members in Indian population: An assessment of neutrophil chemotaxis, phagocytosis, and microbicidal activity

Rahul Suresh Bhansali  1 , Ramreddy Krishnarao Yeltiwar  2 , Kishore Bhat  3
Affiliations

Evaluation of peripheral neutrophil functions in aggressive periodontitis patients and their family members in Indian population: An assessment of neutrophil chemotaxis, phagocytosis, and microbicidal activity

Rahul Suresh Bhansali et al. J Indian Soc Periodontol. 2017 Nov-Dec.

Abstract

Background: Association of neutrophil function abnormalities with localized aggressive periodontitis (LAP) has been reported in Indian population. There are no published studies on the familial aggregation of aggressive periodontitis (AP) and neutrophil function abnormalities associated with it in Indian population. The present study aimed to assess neutrophil chemotaxis, phagocytosis, and microbicidal activity in AP patients and their family members of Indian origin, who may or may not be suffering from AP.

Materials and methods: Eighteen families with a total of 51 individuals (18 probands, 33 family members) were included. Neutrophil chemotaxis was evaluated against an alkali-soluble casein solution using Wilkinson's method. Phagocytosis and microbicidal activity assay were performed using Candida albicans as an indicator organism.

Statistical analysis used: The magnitude of association between the presence of defective neutrophil function and LAP or GAP was calculated using odds ratio and relative risk. Total incidence of AP, and in particular, LAP in the families attributable to the presence of defective neutrophil function was calculated by attributable risk.

Results: The association between depressed neutrophil chemotaxis and presence of AP and LAP or GAP in all the family members (n = 51) was found to be significant (P < 0.05) while that for phagocytic and microbicidal activity were observed to be nonsignificant.

Conclusion: The results of the present study suggest high incidence of AP (LAP and GAP) within families was associated with depressed neutrophil chemotaxis. High prevalence of depressed neutrophil chemotaxis in the family members (61%) of LAP probands exhibiting depressed chemotaxis suggests that the observed abnormalities in neutrophil functions may also be inherited by the family members.

Keywords: Abnormal neutrophil function; Indian population; familial aggregation; localized aggressive periodontitis.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Graph 1
Graph 1
Distributions of localized aggressive periodontitis and generalized aggressive periodontitis in the probands and the rest of the family members participating in the study. LAP – Localized aggressive periodontitis, GAP – Generalized aggressive periodontitis, HM – Healthy members
Graph 2
Graph 2
Prevalence of localized aggressive periodontitis and generalized aggressive periodontitis among the family members of the respective probands. LAP – Localized aggressive periodontitis, GAP – Generalized aggressive periodontitis, HM – Healthy members, n - sample size
Graph 3
Graph 3
Distribution of defective neutrophil functions in family members of the probands with localized aggressive periodontitis and respective neutrophil function defect. LAP – Localized aggressive periodontitis, GAP – Generalized aggressive periodontitis, HM – Healthy members
Graph 4
Graph 4
Distribution of defective neutrophil functions in family members of the probands with generalized aggressive periodontitis and respective neutrophil function defect. LAP – Localized aggressive periodontitis, GAP – Generalized aggressive periodontitis, HM – Healthy members
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