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. 2017 Fall;16(4):1639-1647.

Clinical and Immunological Efficacy of Aspirin Desensitization in Nasal Polyp Patients with Aspirin-Exacerbated Respiratory Disease

Negar Mortazavi  1 , Hossein Esmaeilzadeh  2 , Mohammad Abbasinazari  1 , Delara Babaie  3 , Soheila Alyasin  2 , Hesamodin Nabavizadeh  2 , Elmira Esmailzadeh  4
Affiliations

Clinical and Immunological Efficacy of Aspirin Desensitization in Nasal Polyp Patients with Aspirin-Exacerbated Respiratory Disease

Negar Mortazavi et al. Iran J Pharm Res. 2017 Fall.

Abstract

This study aimed to investigate the efficacy and the underlining mechanism of aspirin desensitization among patients with Aspirin Exacerbated Respiratory Disease (AERD). Thirty-eight patients, who had undergone an aspirin challenge test and were diagnosed as having AERD, were engaged in a double-blind randomized clinical trial. They were divided into two groups-an active group of patients who went through aspirin desensitization, and the control group, receiving placebo. Clinical symptoms and the quality of life of the patients-in addition to the levels of interleukin 4 and 5 (IL4), (IL5)-were documented at the beginning of the study and again after six months of aspirin desensitization. The quality of life of the patients was significantly higher in the active group after six months (P = 0.001). Medication requirements and symptom score were manifested to be significantly lower in the active group after six months than at the beginning of the study (P = 0.005, 0.017 respectively). Forced expiratory volume in the second one (FEV1) was, also, significantly higher in the active group after six months of the study (P = 0.032). IL5 was found to be significantly lower in the active group after six months (P = 0.019). However, no significant difference was observed in the levels of IL4 between the two groups (P = 0.152). The study revealed that aspirin desensitization can improve the quality of life of patients with AERD, lessen their symptoms and medication requirements, lower their levels of IL5, and improve some pulmonary function tests such as FEV1.

Keywords: AERD; Aspirin; Desensitization; Interleukin-4; Interleukin-5.

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Figures

Figure 1.
Figure 1.
The number of patients entered in the study and remained up to end of the study
Figure 2
Figure 2
Interleukin 5 (IL5) mean values in experimental group (underwent aspirin desensitization) and control group (receiving placebo
Figure 3
Figure 3
Interleukin 4(IL4) mean values in experimental group (underwent aspirin desensitization) and control group (receiving placebo
See this image and copyright information in PMC

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