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Review
. 2017 Dec 21;9(15):12487-12502.
doi: 10.18632/oncotarget.23552. eCollection 2018 Feb 23.

The role of exosomal non-coding RNAs in cancer metastasis

Jin-Peng Wang  1   2   3 , Yan-Yan Tang  1   2 , Chun-Mei Fan  2 , Can Guo  2 , Yan-Hong Zhou  2 , Zheng Li  2 , Xiao-Ling Li  2 , Yong Li  2   4 , Gui-Yuan Li  1   2   3 , Wei Xiong  1   2   3 , Zhao-Yang Zeng  1   2   3 , Fang Xiong  1
Affiliations
Review

The role of exosomal non-coding RNAs in cancer metastasis

Jin-Peng Wang et al. Oncotarget. .

Abstract

An increasing number of studies has confirmed that many cells can secrete vesicles or exosomes in eukaryotes, which contain important nucleic acids, proteins and lipids and play important roles in cell communication and tumor metastasis. This paper summarizes the comprehensive function of exosomal non-coding RNAs. Although some studies have shown that exosomes mediate tumor signal transduction, the functional mechanism of the tumor metastasis remains to be elucidated. In this paper, we reviewed the role of exosomal non-coding RNAs in mediating cancer metastasis in the tumor microenvironment to provide new ideas for the study of tumor pathophysiology.

Keywords: exosome; non-coding RNA; tumor metastasis; tumor microenvironment.

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Conflict of interest statement

CONFLICTS OF INTEREST None.

Figures

Figure 1
Figure 1. Exosomal ncRNAs ingested by a receptor cell
Exosomal ncRNAs ingested by a receptor cell via direct fusion, endocytosis and binding of receptor ligands.
Figure 2
Figure 2. The mechanisms of the exosomal ncRNAs involved in cancer metastasis
(1). Horizontal transmission of oncogenes, (2). Regulate the immune system as immunomodulators, (3). Participate in tumor chemotherapy resistance, (4). Regulate tumor metabolism, (5). Influence the progression of EMT and cancer premetastatic niches, (6). Promote angiogenesis.
See this image and copyright information in PMC

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