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Review
. 2018 Jan 6;9(4):638-649.
doi: 10.7150/jca.21180. eCollection 2018.

Human salivary microRNAs in Cancer

Óscar Rapado-González  1   2 , Blanca Majem  3 , Laura Muinelo-Romay  2 , Ana Álvarez-Castro  4 , Anna Santamaría  3 , Antonio Gil-Moreno  3   5 , Rafael López-López  2 , María Mercedes Suárez-Cunqueiro  1
Affiliations
Review

Human salivary microRNAs in Cancer

Óscar Rapado-González et al. J Cancer. .

Abstract

Circulating microRNAs (miRNAs) have emerged as excellent candidates for cancer biomarkers. Several recent studies have highlighted the potential use of saliva for the identification of miRNAs as novel biomarkers, which represents a great opportunity to improve diagnosis and monitor general health and disease. This review summarises the mechanisms of miRNAs deregulation in cancer, the value of targeting them with a therapeutic intention and the evidence of the potential clinical use of miRNAs expressed in saliva for the detection of different cancer types. We also provide a comprehensive review of the different methods for normalising the levels of specific miRNAs present in saliva, as this is a critical step in their analysis, and the challenge to validate salivary miRNAs as a reality to manage cancer patients.

Keywords: biomarkers; cancer; liquid biopsy; miRNAs; normalization; saliva.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Salivary miRNAs in cancer diagnosis.
See this image and copyright information in PMC

References

    1. Falco M, Palma G, Rea D. et al. Tumour biomarkers: homeostasis as a novel prognostic indicator. Open Biol. 2016;6(12pii):160254. - PMC - PubMed
    1. Kishore L, Kaur N, Singh R. Distinct biomarkers for early diagnosis of diabetic nephropathy. Curr Diabetes Rev. 2017;13(6):598–605. [Epub ahead of print] - PubMed
    1. Bidard FC, Proudhon C, Pierga JY. Circulating tumor cells in breast cancer. Mol Oncol. 2016;10(3):418–30. - PMC - PubMed
    1. Song Y, Zhang W, Zhang L. et al. Cerebrospinal fluid IL-10 and IL-10/IL-6 as accurate diagnostic biomarkers for primary central nervous system large B-cell lymphoma. Sci Rep. 2016;6:38671. - PMC - PubMed
    1. Lee YH, Wong DT. Saliva: an emerging biofluid for early detection of diseases. Am J Dent. 2009;22(4):241–8. - PMC - PubMed