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. 2018 Mar 13;3(2):e00190-17.
doi: 10.1128/mSystems.00190-17. eCollection 2018 Mar-Apr.

On the Road to Strain-Resolved Comparative Metagenomics

Nicola Segata  1
Affiliations

On the Road to Strain-Resolved Comparative Metagenomics

Nicola Segata. mSystems. .

Abstract

Metagenomics has transformed microbiology, but its potential has not been fully expressed yet. From computational methods for digging deeper into metagenomes to study designs for addressing specific hypotheses, the Segata Lab is pursuing an integrative metagenomic approach to describe and model human-associated microbial communities as collections of strains. Linking strain variants to host phenotypes and performing cultivation-free population genomics require large cohorts and meta-analysis strategies to synthesize available cohorts but can revolutionize our understanding of the personalized host-microbiome interface which is at the base of human health.

Keywords: comparative microbial genomics; computational biology; human microbiome; metagenomics; strain profiling.

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Conflict of interest statement

Conflict of Interest Disclosures: N.S. has nothing to disclose. Conflict of Interest Disclosures: N.S. has nothing to disclose.

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