Imaging the myocardial ischemic cascade

Arthur E Stillman¹, Matthijs Oudkerk², David A Bluemke³, Menko Jan de Boer⁴, Jens Bremerich⁵, Ernest V Garcia⁶, Matthias Gutberlet⁷, Pim van der Harst⁸, W Gregory Hundley⁹, Michael Jerosch-Herold¹⁰, Dirkjan Kuijpers¹¹, Raymond Y Kwong¹², Eike Nagel¹³, Stamatios Lerakis¹⁴, John Oshinski⁶, Jean-François Paul¹⁵, Riemer H J A Slart¹⁶, Vinod Thourani¹⁷, Rozemarijn Vliegenthart¹⁸, Bernd J Wintersperger¹⁹

Affiliations

¹ Department of Radiology and Imaging Sciences, Emory University, 1365 Clifton Rd NE, Atlanta, GA, 30322, USA. aestill@emory.edu.
² Center of Medical Imaging, University Medical Center Groningen, Groningen, The Netherlands.
³ Department of Radiology and Imaging Sciences, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA.
⁴ Department of Cardiology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands.
⁵ Department of Radiology, University of Basel Hospital, Basel, Switzerland.
⁶ Department of Radiology and Imaging Sciences, Emory University, 1365 Clifton Rd NE, Atlanta, GA, 30322, USA.
⁷ Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.
⁸ Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.
⁹ Departments of Internal Medicine & Radiology, Wake Forest University, Winston-Salem, NC, USA.
¹⁰ Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
¹¹ Department of Radiology, Haaglanden Medical Center, The Hague, The Netherlands.
¹² Department of Cardiology, Brigham and Women's Hospital, Boston, MA, USA.
¹³ Institute for Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, University Hospital, Frankfurt/Main, Germany.
¹⁴ Department of Medicine, Emory University, Atlanta, GA, USA.
¹⁵ Department of Radiology, Institut Mutualiste Montsouris, Paris, France.
¹⁶ Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
¹⁷ Department of Cardiac Surgery, MedStar Heart and Vascular Institute, Georgetown University, Washington, DC, USA.
¹⁸ Department of Radiology, University Medical Center Groningen, Groningen, The Netherlands.
¹⁹ Department of Medical Imaging, University of Toronto, Toronto, Canada.

PMID: 29556943
DOI: 10.1007/s10554-018-1330-4

Review

Imaging the myocardial ischemic cascade

Arthur E Stillman et al. Int J Cardiovasc Imaging. 2018 Aug.

. 2018 Aug;34(8):1249-1263.

doi: 10.1007/s10554-018-1330-4. Epub 2018 Mar 19.

Authors

Affiliations

¹ Department of Radiology and Imaging Sciences, Emory University, 1365 Clifton Rd NE, Atlanta, GA, 30322, USA. aestill@emory.edu.
² Center of Medical Imaging, University Medical Center Groningen, Groningen, The Netherlands.
³ Department of Radiology and Imaging Sciences, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA.
⁴ Department of Cardiology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands.
⁵ Department of Radiology, University of Basel Hospital, Basel, Switzerland.
⁶ Department of Radiology and Imaging Sciences, Emory University, 1365 Clifton Rd NE, Atlanta, GA, 30322, USA.
⁷ Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.
⁸ Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.
⁹ Departments of Internal Medicine & Radiology, Wake Forest University, Winston-Salem, NC, USA.
¹⁰ Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
¹¹ Department of Radiology, Haaglanden Medical Center, The Hague, The Netherlands.
¹² Department of Cardiology, Brigham and Women's Hospital, Boston, MA, USA.
¹³ Institute for Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, University Hospital, Frankfurt/Main, Germany.
¹⁴ Department of Medicine, Emory University, Atlanta, GA, USA.
¹⁵ Department of Radiology, Institut Mutualiste Montsouris, Paris, France.
¹⁶ Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
¹⁷ Department of Cardiac Surgery, MedStar Heart and Vascular Institute, Georgetown University, Washington, DC, USA.
¹⁸ Department of Radiology, University Medical Center Groningen, Groningen, The Netherlands.
¹⁹ Department of Medical Imaging, University of Toronto, Toronto, Canada.

PMID: 29556943
DOI: 10.1007/s10554-018-1330-4

Erratum in

Correction to: Imaging the myocardial ischemic cascade.
Stillman AE, Oudkerk M, Bluemke DA, de Boer MJ, Bremerich J, Garcia EV, Gutberlet M, van der Harst P, Hundley WG, Jerosch-Herold M, Kuijpers D, Kwong RY, Nagel E, Lerakis S, Oshinski J, Paul JF, Slart RHJA, Thourani V, Vliegenthart R, Wintersperger BJ. Stillman AE, et al. Int J Cardiovasc Imaging. 2018 Sep;34(9):1503. doi: 10.1007/s10554-018-1408-z. Int J Cardiovasc Imaging. 2018. PMID: 30043233

Abstract

Non-invasive imaging plays a growing role in the diagnosis and management of ischemic heart disease from its earliest manifestations of endothelial dysfunction to myocardial infarction along the myocardial ischemic cascade. Experts representing the North American Society for Cardiovascular Imaging and the European Society of Cardiac Radiology have worked together to organize the role of non-invasive imaging along the framework of the ischemic cascade. The current status of non-invasive imaging for ischemic heart disease is reviewed along with the role of imaging for guiding surgical planning. The issue of cost effectiveness is also considered. Preclinical disease is primarily assessed through the coronary artery calcium score and used for risk assessment. Once the patient becomes symptomatic, other imaging tests including echocardiography, CCTA, SPECT, PET and CMR may be useful. CCTA appears to be a cost-effective gatekeeper. Post infarction CMR and PET are the preferred modalities. Imaging is increasingly used for surgical planning of patients who may require coronary artery bypass.

Keywords: Cardiac imaging; Coronary artery disease; Ischemic heart disease.

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References

1. Eur Heart J. 2013 Mar;34(10):775-81 - PubMed
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Imaging the myocardial ischemic cascade

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Imaging the myocardial ischemic cascade

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